| Conţinutul numărului revistei |
| Articolul precedent |
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 SM ISO690:2012FUIOR, Arcadie, HIJAZI, Akram, GARBUZ, Olga, BULIMAGA, Valentina, ZOSIM, Liliana, CEBOTARI, Diana, HAOUAS, Mohamed, TODERASH, Ion, GULYA, Aurelian, FLOQUET, Sebastian. Screening of biological properties of MoV 2O2S2- and MoV 2O4-based coordination complexes: Investigation of antibacterial, antifungal, antioxidative and antitumoral activities versus growing of Spirulina platensis biomass. In: Journal of Inorganic Biochemistry, 2022, vol. 226, p. 0. ISSN 0162-0134. DOI: https://doi.org/10.1016/j.jinorgbio.2021.111627 |
| EXPORT metadate: Google Scholar Crossref CERIF DataCite Dublin Core |
  Journal of Inorganic Biochemistry |
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| Volumul 226 / 2022 / ISSN 0162-0134 /ISSNe 1873-3344 | ||||||
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| DOI:https://doi.org/10.1016/j.jinorgbio.2021.111627 | ||||||
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This paper deals with the biological potential of coordination compounds based on binuclear core [MoV2O2E2]2+ (E = O or S) coordinated with commercially available ligands such as oxalates (Ox2−), L-cysteine (L-cys2−), L-histidine (L-his−), Iminodiacetate (IDA2−), Nitrilotriacetate (HNTA2− or NTA3−) or ethylenediamine tetraacetate (EDTA4−) by means of various in vitro assays in a screening approach. Results suggest that the obtained complexes show weak antibacterial and antifungal properties while not being cytotoxic on cancerous and mammalian cells. In contrast, [Mo2O2E2(L-cys)2]2− complexes stand out as powerful antioxidant, whereas [Mo2O2E2(EDTA)]2− associating tetraphenylphosphonium counter-cations display strong antibiotic activity. Finally, some complexes have evidenced a positive activity towards the growing of spirulina platensis together with a modification of the proportions of biological components inside the cells. These findings reveal promising bioactivity of the bridged binuclear Mo(+V) cores inside complexes and encourage further research for new highly active yet non-toxic molecules for biological and biomedical applications. |
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| Cuvinte-cheie Antibiotic activity, Cluster, complex, cytotoxicity, molybdenum, Spirulina platensis |
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Dublin Core Export
<?xml version='1.0' encoding='utf-8'?> <oai_dc:dc xmlns:dc='http://purl.org/dc/elements/1.1/' xmlns:oai_dc='http://www.openarchives.org/OAI/2.0/oai_dc/' xmlns:xsi='http://www.w3.org/2001/XMLSchema-instance' xsi:schemaLocation='http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd'> <dc:creator>Fuior, A.</dc:creator> <dc:creator>Hijazi, A.</dc:creator> <dc:creator>Garbuz, O.S.</dc:creator> <dc:creator>Bulimaga, V.P.</dc:creator> <dc:creator>Zosim, L.</dc:creator> <dc:creator>Cebotari, D.</dc:creator> <dc:creator>Haouas, M.</dc:creator> <dc:creator>Toderaş, I.C.</dc:creator> <dc:creator>Gulea, A.P.</dc:creator> <dc:creator>Floquet, S.</dc:creator> <dc:date>2022-01-06</dc:date> <dc:description xml:lang='en'><p>This paper deals with the biological potential of coordination compounds based on binuclear core [Mo<sup>V</sup><sub>2</sub>O<sub>2</sub>E<sub>2</sub>]<sup>2+</sup> (E = O or S) coordinated with commercially available ligands such as oxalates (Ox<sup>2−</sup>), L-cysteine (L-cys<sup>2−</sup>), L-histidine (L-his<sup>−</sup>), Iminodiacetate (IDA<sup>2−</sup>), Nitrilotriacetate (HNTA<sup>2−</sup> or NTA<sup>3−</sup>) or ethylenediamine tetraacetate (EDTA<sup>4−</sup>) by means of various in vitro assays in a screening approach. Results suggest that the obtained complexes show weak antibacterial and antifungal properties while not being cytotoxic on cancerous and mammalian cells. In contrast, [Mo<sub>2</sub>O<sub>2</sub>E<sub>2</sub>(L-cys)<sub>2</sub>]<sup>2−</sup> complexes stand out as powerful antioxidant, whereas [Mo<sub>2</sub>O<sub>2</sub>E<sub>2</sub>(EDTA)]<sup>2−</sup> associating tetraphenylphosphonium counter-cations display strong antibiotic activity. Finally, some complexes have evidenced a positive activity towards the growing of spirulina platensis together with a modification of the proportions of biological components inside the cells. These findings reveal promising bioactivity of the bridged binuclear Mo<sup>(+V)</sup> cores inside complexes and encourage further research for new highly active yet non-toxic molecules for biological and biomedical applications.</p></dc:description> <dc:identifier>10.1016/j.jinorgbio.2021.111627</dc:identifier> <dc:source>Journal of Inorganic Biochemistry () 0-0</dc:source> <dc:subject>Antibiotic activity</dc:subject> <dc:subject>Cluster</dc:subject> <dc:subject>complex</dc:subject> <dc:subject>cytotoxicity</dc:subject> <dc:subject>molybdenum</dc:subject> <dc:subject>Spirulina platensis</dc:subject> <dc:title>Screening of biological properties of MoV 2O2S2- and MoV 2O4-based coordination complexes: Investigation of antibacterial, antifungal, antioxidative and antitumoral activities versus growing of Spirulina platensis biomass</dc:title> <dc:type>info:eu-repo/semantics/article</dc:type> </oai_dc:dc>
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