Screening of biological properties of MoV 2O2S2- and MoV 2O4-based coordination complexes: Investigation of antibacterial, antifungal, antioxidative and antitumoral activities versus growing of Spirulina platensis biomass

Fuior Arcadie; Hijazi Akram; Garbuz Olga; Bulimaga Valentina; Zosim Liliana; Cebotari Diana; Haouas Mohamed; Toderash Ion; Gulya Aurelian; Floquet Sebastian

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FUIOR, Arcadie, HIJAZI, Akram, GARBUZ, Olga, BULIMAGA, Valentina, ZOSIM, Liliana, CEBOTARI, Diana, HAOUAS, Mohamed, TODERASH, Ion, GULYA, Aurelian, FLOQUET, Sebastian. Screening of biological properties of MoV 2O2S2- and MoV 2O4-based coordination complexes: Investigation of antibacterial, antifungal, antioxidative and antitumoral activities versus growing of Spirulina platensis biomass. In: Journal of Inorganic Biochemistry, 2022, vol. 226, p. 0. ISSN 0162-0134. DOI: https://doi.org/10.1016/j.jinorgbio.2021.111627

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Journal of Inorganic Biochemistry

Volumul 226 / 2022 / ISSN 0162-0134 /ISSNe 1873-3344

Screening of biological properties of MoV 2O2S2- and MoV 2O4-based coordination complexes: Investigation of antibacterial, antifungal, antioxidative and antitumoral activities versus growing of Spirulina platensis biomass

DOI:https://doi.org/10.1016/j.jinorgbio.2021.111627

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Fuior Arcadie¹², Hijazi Akram¹, Garbuz Olga², Bulimaga Valentina², Zosim Liliana², Cebotari Diana³², Haouas Mohamed³, Toderash Ion⁴, Gulya Aurelian², Floquet Sebastian¹

¹ Institut Lavoisier de Versailles,
² Moldova State University,
³ Institut Lavoisier of Versailles, University of Versailles,
⁴ Institute of Zoology

Disponibil în IBN: 31 octombrie 2021

Rezumat

This paper deals with the biological potential of coordination compounds based on binuclear core [Mo^V₂O₂E₂]²⁺ (E = O or S) coordinated with commercially available ligands such as oxalates (Ox²⁻), L-cysteine (L-cys²⁻), L-histidine (L-his⁻), Iminodiacetate (IDA²⁻), Nitrilotriacetate (HNTA²⁻ or NTA³⁻) or ethylenediamine tetraacetate (EDTA⁴⁻) by means of various in vitro assays in a screening approach. Results suggest that the obtained complexes show weak antibacterial and antifungal properties while not being cytotoxic on cancerous and mammalian cells. In contrast, [Mo₂O₂E₂(L-cys)₂]²⁻ complexes stand out as powerful antioxidant, whereas [Mo₂O₂E₂(EDTA)]²⁻ associating tetraphenylphosphonium counter-cations display strong antibiotic activity. Finally, some complexes have evidenced a positive activity towards the growing of spirulina platensis together with a modification of the proportions of biological components inside the cells. These findings reveal promising bioactivity of the bridged binuclear Mo^(+V) cores inside complexes and encourage further research for new highly active yet non-toxic molecules for biological and biomedical applications.

Cuvinte-cheie
Antibiotic activity, Cluster, complex, cytotoxicity, molybdenum, Spirulina platensis

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