Synthesis and biologic properties of some1-(alchyl) phenyl-3-(4-(3-(pyridin-2 il) acryloyl)phenylthiourea
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POPUSOI, Ana; BARBA, Nicanor; GULEA, Aurelian; ROY, Jenny; POIRIER, Donald; PRISACARI, Viorel. Synthesis and biologic properties of some1-(alchyl) phenyl-3-(4-(3-(pyridin-2 il) acryloyl)phenylthiourea . In: Chemistry Journal of Moldova. 2013, nr. 1(8), pp. 83-89. ISSN 1857-1727.
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Chemistry Journal of Moldova
Numărul 1(8) / 2013 / ISSN 1857-1727 /ISSNe 2345-1688

Synthesis and biologic properties of some1-(alchyl) phenyl-3-(4-(3-(pyridin-2 il) acryloyl)phenylthiourea

Pag. 83-89

Popusoi Ana1, Barba Nicanor1, Gulea Aurelian1, Roy Jenny2, Poirier Donald2, Prisacari Viorel3
 
1 State University of Moldova,
2 Université Laval, Québec,
3 ”Nicolae Testemițanu” State University of Medicine and Pharmacy
 
Disponibil în IBN: 1 decembrie 2013


Rezumat

This paper describe the synthesis of some 1-(alchyl)aril-3-(4-(3-pyridin-2-il) acryloyl)phenylthiourea obtained by condensation of 2-pyridincarboxaldehide with some derivatives of 4-acetylphenilthioureas in basic medium or by addition of aliphatic and aromatic amines to the correspondingisothiocyanatopropenones. 12 new compounds were obtained and their biological properties were analysed. The substituted thioureas by pyridine radicals, morpholine and phenol show a maximum bacteriostatic activity for Gram positive microorganisms like: Staphylococcus Aureus and Enterococcus Faecalis at the minimum inhibitory concentration 9.37-37.5 μM. Antifungal activity for Candida Albicans, Aspergillus Niger, AspergillusFumigatus, Penicillium is weak, in minimum inhibitory concentration 600->600 μM. The leukemia activity like inhibitor (HL-60), is 84-96.9% at the concentration 10-5mol/l and 15-20% and at the concentrations 10-6, 10-7mol/l.

Cuvinte-cheie
chalcones, isothiocyanatopropenones, thioureas, antiproliferative activity,

antibacterial activity, Antifungal activity