Synthesis and biologic properties of some1-(alchyl) phenyl-3-(4-(3-(pyridin-2 il) acryloyl)phenylthiourea
Închide
Conţinutul numărului revistei
Articolul precedent
Articolul urmator
677 1
Ultima descărcare din IBN:
2017-04-07 22:42
SM ISO690:2012
POPUSHOI, Ana; BARBA, Nicanor; GULEA, Aurelian; ROY, Jenny; POIRIER, Donald; PRISAKARI, Viorel I.. Synthesis and biologic properties of some1-(alchyl) phenyl-3-(4-(3-(pyridin-2 il) acryloyl)phenylthiourea . In: Chemistry Journal of Moldova. 2013, nr. 1(8), pp. 83-89. ISSN 1857-1727.
EXPORT metadate:
Google Scholar
Crossref
CERIF
BibTeX
DataCite
Dublin Core
Chemistry Journal of Moldova
Numărul 1(8) / 2013 / ISSN 1857-1727 /ISSNe 2345-1688

Synthesis and biologic properties of some1-(alchyl) phenyl-3-(4-(3-(pyridin-2 il) acryloyl)phenylthiourea

Pag. 83-89

Popushoi Ana1, Barba Nicanor1, Gulea Aurelian1, Roy Jenny2, Poirier Donald2, Prisakari Viorel I.3
 
1 State University of Moldova,
2 Université Laval, Québec,
3 ”Nicolae Testemițanu” State University of Medicine and Pharmacy
 
Disponibil în IBN: 1 decembrie 2013


Rezumat

This paper describe the synthesis of some 1-(alchyl)aril-3-(4-(3-pyridin-2-il) acryloyl)phenylthiourea obtained by condensation of 2-pyridincarboxaldehide with some derivatives of 4-acetylphenilthioureas in basic medium or by addition of aliphatic and aromatic amines to the correspondingisothiocyanatopropenones. 12 new compounds were obtained and their biological properties were analysed. The substituted thioureas by pyridine radicals, morpholine and phenol show a maximum bacteriostatic activity for Gram positive microorganisms like: Staphylococcus Aureus and Enterococcus Faecalis at the minimum inhibitory concentration 9.37-37.5 μM. Antifungal activity for Candida Albicans, Aspergillus Niger, AspergillusFumigatus, Penicillium is weak, in minimum inhibitory concentration 600->600 μM. The leukemia activity like inhibitor (HL-60), is 84-96.9% at the concentration 10-5mol/l and 15-20% and at the concentrations 10-6, 10-7mol/l.

Cuvinte-cheie
chalcones, isothiocyanatopropenones, thioureas, antibacterial activity, Antifungal activity,

antiproliferative activity

Crossref XML Export

<?xml version='1.0' encoding='utf-8'?>
<doi_batch version='4.3.7' xmlns='http://www.crossref.org/schema/4.3.7' xmlns:xsi='http://www.w3.org/2001/XMLSchema-instance' xsi:schemaLocation='http://www.crossref.org/schema/4.3.7 http://www.crossref.org/schema/deposit/crossref4.3.7.xsd'>
<head>
<doi_batch_id>ibn-26100</doi_batch_id>
<timestamp>1606270846</timestamp>
<depositor>
<depositor_name>Information Society Development Instiute, Republic of Moldova</depositor_name>
<email_address>idsi@asm.md</email_address>
</depositor>
<registrant>Institutul de Chimie al AŞM</registrant>
</head>
<body>
<journal>
<journal_metadata>
<full_title>Chemistry Journal of Moldova</full_title>
<issn media_type='print'>18571727</issn>
<doi_data>
<doi>10.19261</doi>
<resource>http://www.crossref.org/</resource>
</doi_data>
</journal_metadata>
<journal_issue>
<publication_date media_type='print'>
<year>2013</year>
</publication_date>
<issue>1(8)</issue>
</journal_issue>
<journal_article publication_type='full_text'><titles>
<title>Synthesis and biologic properties of some1-(alchyl) phenyl-3-(4-(3-(pyridin-2 il)
acryloyl)phenylthiourea
</title>
</titles>
<contributors>
<person_name sequence='first' contributor_role='author'>
<given_name>Ana</given_name>
<surname>Popuşoi</surname>
</person_name>
<person_name sequence='additional' contributor_role='author'>
<given_name>Nicanor</given_name>
<surname>Barbă</surname>
</person_name>
<person_name sequence='additional' contributor_role='author'>
<given_name>Aurelian</given_name>
<surname>Gulea</surname>
</person_name>
<person_name sequence='additional' contributor_role='author'>
<given_name>Jenny</given_name>
<surname>Roy</surname>
</person_name>
<person_name sequence='additional' contributor_role='author'>
<given_name>Donald</given_name>
<surname>Poirier</surname>
</person_name>
<person_name sequence='additional' contributor_role='author'>
<given_name>Viorel</given_name>
<surname>Prisacari</surname>
</person_name>
</contributors>
<publication_date media_type='print'>
<year>2013</year>
</publication_date>
<pages>
<first_page>83</first_page>
<last_page>89</last_page>
</pages>
</journal_article>
</journal>
</body>
</doi_batch>