Ectonucleotidase Inhibitory and Redox Activity of Imidazole-Based Organic Salts and Ionic Liquids

Boldescu Veaceslav; Sucman Natalia; Hassan Sidra; Iqbal Jamshed; Neamţu Mariana; Lecka  Joanna; Sevigny Jean; Prodius Denis; Makaev Fliur

Conţinutul numărului revistei

Articolul precedent

Articolul urmator

941

SM ISO690:2012

BOLDESCU, Veaceslav, SUCMAN, Natalia, HASSAN, Sidra, IQBAL, Jamshed, NEAMŢU, Mariana, LECKA , Joanna, SEVIGNY, Jean, PRODIUS, Denis, MAKAEV, Fliur. Ectonucleotidase Inhibitory and Redox Activity of Imidazole-Based Organic Salts and Ionic Liquids. In: ChemMedChem, 2018, nr. 13(21), pp. 2297-2304. ISSN 1860-7179. DOI: https://doi.org/10.1002/cmdc.201800520

EXPORT metadate:
Google Scholar
Crossref
CERIF

DataCite
Dublin Core

ChemMedChem

Numărul 13(21) / 2018 / ISSN 1860-7179

Ectonucleotidase Inhibitory and Redox Activity of Imidazole-Based Organic Salts and Ionic Liquids

DOI:https://doi.org/10.1002/cmdc.201800520

Pag. 2297-2304

Boldescu Veaceslav¹, Sucman Natalia¹, Hassan Sidra², Iqbal Jamshed², Neamţu Mariana³, Lecka Joanna⁴, Sevigny Jean⁴, Prodius Denis¹⁵, Makaev Fliur¹

¹ Institute of Chemistry of the Academy of Sciences of Moldova,
² COMSATS Institute of Information Technology,
³ Alexandru Ioan Cuza University of Iaşi,
⁴ Université Laval, Québec,
⁵ Ames Laboratory, US Department of Energy and Critical Materials Institute, Ames, IA

Disponibil în IBN: 3 decembrie 2018

Rezumat

Cytotoxicity against cancer and normal cells, inhibition of ectonucleotidase, and redox properties of a new group of imidazole-based organic salts and ionic liquids were studied. The tetrachloroferrate salt of a 1-methylimidazole derivative of salicylic aldehyde had most prominent inhibitory activity against ectonucleotidase as well as a higher cytotoxicity against HeLa cells and lower cytotoxicity against BHK-21 cells than the reference compound carboplatin. The studied compounds exhibited a moderate level of antioxidant activity with better results for the salicylic aldehyde derivatives than for spiropyrans. Moreover, these compounds did not generate singlet oxygen.

Cuvinte-cheie
antioxidants, cancer, ectonucleotidase, ionic liquids, organic salts

Google Scholar Export

<meta name="citation_title" content="Ectonucleotidase Inhibitory and Redox Activity of Imidazole-Based Organic Salts and Ionic Liquids">
<meta name="citation_author" content="Boldescu Veaceslav">
<meta name="citation_author" content="Sucman Natalia">
<meta name="citation_author" content="Hassan Sidra">
<meta name="citation_author" content="Iqbal Jamshed">
<meta name="citation_author" content="Neamţu Mariana">
<meta name="citation_author" content="Lecka  Joanna">
<meta name="citation_author" content="Sevigny Jean">
<meta name="citation_author" content="Prodius Denis">
<meta name="citation_author" content="Makaev Fliur">
<meta name="citation_publication_date" content="2018/11/06">
<meta name="citation_journal_title" content="ChemMedChem">
<meta name="citation_volume" content="21">
<meta name="citation_issue" content="13">
<meta name="citation_firstpage" content="2297">
<meta name="citation_lastpage" content="2304">
<meta name="citation_pdf_url" content="https://onlinelibrary.wiley.com/doi/abs/10.1002/cmdc.201800520">