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Articolul precedent |
Articolul urmator |
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SM ISO690:2012 BOLDESCU, Veaceslav, SUCMAN, Natalia, HASSAN, Sidra, IQBAL, Jamshed, NEAMŢU, Mariana, LECKA , Joanna, SEVIGNY, Jean, PRODIUS, Denis, MAKAEV, Fliur. Ectonucleotidase Inhibitory and Redox Activity of Imidazole-Based Organic Salts and Ionic Liquids. In: ChemMedChem, 2018, nr. 13(21), pp. 2297-2304. ISSN 1860-7179. DOI: https://doi.org/10.1002/cmdc.201800520 |
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ChemMedChem | |
Numărul 13(21) / 2018 / ISSN 1860-7179 | |
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DOI: https://doi.org/10.1002/cmdc.201800520 | |
Pag. 2297-2304 | |
Rezumat | |
Cytotoxicity against cancer and normal cells, inhibition of ectonucleotidase, and redox properties of a new group of imidazole-based organic salts and ionic liquids were studied. The tetrachloroferrate salt of a 1-methylimidazole derivative of salicylic aldehyde had most prominent inhibitory activity against ectonucleotidase as well as a higher cytotoxicity against HeLa cells and lower cytotoxicity against BHK-21 cells than the reference compound carboplatin. The studied compounds exhibited a moderate level of antioxidant activity with better results for the salicylic aldehyde derivatives than for spiropyrans. Moreover, these compounds did not generate singlet oxygen. |
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Cuvinte-cheie antioxidants, cancer, ectonucleotidase, ionic liquids, organic salts |
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