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 SM ISO690:2012GULYA, Aurelian, CEBOTARI, Diana, BALAN, Greta, BURDUNIUC (POPA), Olga, TSAPKOV, Victor I., RUDIK, V.. Synthesis, structure and antimicrobial activity of some 3d-metal coordination compounds with 2-hydroxy-3-methoxybenzaldehyde 4-(dimethylphenyl)thiosemicarbazones. In: French-Romanian Colloquium on Medicinal Chemistry, Ed. 4, 5-7 octombrie 2017, Iași. Iași : “Alexandru Ioan Cuza” University of Iasi, 2017, Ediţia 4, p. 72. |
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| French-Romanian Colloquium on Medicinal Chemistry Ediţia 4, 2017 |
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Colocviul "4th French-Romanian Colloquium on Medicinal Chemistry" 4, Iași, Romania, 5-7 octombrie 2017 | |||||||
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The aim of this work is the synthesis, determination of the composition, structure, physicochemical, antimicrobial and antifungal properties of 2-hydroxy-3methoxybenzaldehyde 4-(2,4-dimethylphenyl)thiosemicarbazone (H2L1) and 4-(3,4dimethylphenyl)thiosemicarbazone (H2L2) as well as iron(III), cobalt(III), nickel(II), and copper(II) coordination compounds with these ligands. The thiosemicarbazones H2L1-2 react with chlorides, bromides, nitrates and perchlorates of stated above metals forming colored solutions. Upon cooling the precipitates of coordination compounds are formed: Cu(HL1-2)X • nH2O (X = Cl-, Br-, ClO4-, NO3-, n = 0, 4), Co(HL1-2)2X (X = Cl-, NO3-), Cu(L1-2)H2O, Fe(HL1)2X • nH2O (X = Cl-, NO3-; n = 0, 2), Ni(L1-2)H2O. The composition and structure of these compounds were determined using elemental analysis, magnetochemical research and IR-spectroscopy. It was determined that all coordination compounds have monomeric structure. The thiosemicarbazones H2L1-2 act as tridentate ligands with O, N, S set of donor atoms. Synthesized coordination compounds show selective antimicrobial activity towards a series of standard strains of Staphylococcus aureus, Escherihia coli, and Candida albicans in the range of concentration 0.0039-0.5 mg/mL. It was shown that the nature of the central atom has a main influence on the antimicrobial activity of these complexes. For the homotypic complexes the activity diminishes in the following way: Cu > Ni > Co ≥ Fe. The nature of thiosemicarbazone and acid residue also has an influence on antimicrobial activity. The antimicrobial activity reduces in the following way: H2L1 > H2L2 and NO3- > ClO4-> Cl- ≥ Br-. Synthesized compounds manifest the best activity towards the standard strains of Staphylococcus aureus and Candida albicans. |
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<?xml version='1.0' encoding='utf-8'?> <oai_dc:dc xmlns:dc='http://purl.org/dc/elements/1.1/' xmlns:oai_dc='http://www.openarchives.org/OAI/2.0/oai_dc/' xmlns:xsi='http://www.w3.org/2001/XMLSchema-instance' xsi:schemaLocation='http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd'> <dc:creator>Gulea, A.P.</dc:creator> <dc:creator>Cebotari, D.</dc:creator> <dc:creator>Balan, G.G.</dc:creator> <dc:creator>Burduniuc (Popa), O.S.</dc:creator> <dc:creator>Ţapcov, V.I.</dc:creator> <dc:creator>Rudic, V.F.</dc:creator> <dc:date>2017</dc:date> <dc:description xml:lang='en'><p>The aim of this work is the synthesis, determination of the composition, structure, physicochemical, antimicrobial and antifungal properties of 2-hydroxy-3methoxybenzaldehyde 4-(2,4-dimethylphenyl)thiosemicarbazone (H2L1) and 4-(3,4dimethylphenyl)thiosemicarbazone (H2L2) as well as iron(III), cobalt(III), nickel(II), and copper(II) coordination compounds with these ligands. The thiosemicarbazones H2L1-2 react with chlorides, bromides, nitrates and perchlorates of stated above metals forming colored solutions. Upon cooling the precipitates of coordination compounds are formed: Cu(HL1-2)X • nH2O (X = Cl-, Br-, ClO4-, NO3-, n = 0, 4), Co(HL1-2)2X (X = Cl-, NO3-), Cu(L1-2)H2O, Fe(HL1)2X • nH2O (X = Cl-, NO3-; n = 0, 2), Ni(L1-2)H2O. The composition and structure of these compounds were determined using elemental analysis, magnetochemical research and IR-spectroscopy. It was determined that all coordination compounds have monomeric structure. The thiosemicarbazones H2L1-2 act as tridentate ligands with O, N, S set of donor atoms. Synthesized coordination compounds show selective antimicrobial activity towards a series of standard strains of Staphylococcus aureus, Escherihia coli, and Candida albicans in the range of concentration 0.0039-0.5 mg/mL. It was shown that the nature of the central atom has a main influence on the antimicrobial activity of these complexes. For the homotypic complexes the activity diminishes in the following way: Cu > Ni > Co ≥ Fe. The nature of thiosemicarbazone and acid residue also has an influence on antimicrobial activity. The antimicrobial activity reduces in the following way: H2L1 > H2L2 and NO3- > ClO4-> Cl- ≥ Br-. Synthesized compounds manifest the best activity towards the standard strains of Staphylococcus aureus and Candida albicans.</p></dc:description> <dc:source>French-Romanian Colloquium on Medicinal Chemistry (Ediţia 4) 72-72</dc:source> <dc:title>Synthesis, structure and antimicrobial activity of some 3d-metal coordination compounds with 2-hydroxy-3-methoxybenzaldehyde 4-(dimethylphenyl)thiosemicarbazones</dc:title> <dc:type>info:eu-repo/semantics/article</dc:type> </oai_dc:dc>
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