Synthesis, structure and antimicrobial activity of some 3d-metal coordination compounds with 2-hydroxy-3-methoxybenzaldehyde 4-(dimethylphenyl)thiosemicarbazones

Gulya Aurelian; Cebotari Diana; Balan Greta; Burduniuc (Popa) Olga; Tsapkov Victor I.; Rudik V.

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2024-06-13 17:31

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GULYA, Aurelian, CEBOTARI, Diana, BALAN, Greta, BURDUNIUC (POPA), Olga, TSAPKOV, Victor I., RUDIK, V.. Synthesis, structure and antimicrobial activity of some 3d-metal coordination compounds with 2-hydroxy-3-methoxybenzaldehyde 4-(dimethylphenyl)thiosemicarbazones. In: French-Romanian Colloquium on Medicinal Chemistry, Ed. 4, 5-7 octombrie 2017, Iași. Iași : “Alexandru Ioan Cuza” University of Iasi, 2017, Ediţia 4, p. 72.

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French-Romanian Colloquium on Medicinal Chemistry
Ediţia 4, 2017

Colocviul "4th French-Romanian Colloquium on Medicinal Chemistry"
4, Iași, Romania, 5-7 octombrie 2017

Synthesis, structure and antimicrobial activity of some 3d-metal coordination compounds with 2-hydroxy-3-methoxybenzaldehyde 4-(dimethylphenyl)thiosemicarbazones

Pag. 72-72

Gulya Aurelian¹, Cebotari Diana¹, Balan Greta², Burduniuc (Popa) Olga², Tsapkov Victor I.¹, Rudik V.³

¹ Moldova State University,
² ”Nicolae Testemițanu” State University of Medicine and Pharmacy,
³ Institute of Microbiology and Biotechnology of the ASM

Proiecte:

15.817.02.24F Strategii de elaborare a inhibitorilor moleculari antitumorali de o noua generaţie. Sinteza, proprietăţi şi mecanisme de acţiune

Disponibil în IBN: 18 aprilie 2024

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The aim of this work is the synthesis, determination of the composition, structure, physicochemical, antimicrobial and antifungal properties of 2-hydroxy-3methoxybenzaldehyde 4-(2,4-dimethylphenyl)thiosemicarbazone (H2L1) and 4-(3,4dimethylphenyl)thiosemicarbazone (H2L2) as well as iron(III), cobalt(III), nickel(II), and copper(II) coordination compounds with these ligands. The thiosemicarbazones H2L1-2 react with chlorides, bromides, nitrates and perchlorates of stated above metals forming colored solutions. Upon cooling the precipitates of coordination compounds are formed: Cu(HL1-2)X • nH2O (X = Cl-, Br-, ClO4-, NO3-, n = 0, 4), Co(HL1-2)2X (X = Cl-, NO3-), Cu(L1-2)H2O, Fe(HL1)2X • nH2O (X = Cl-, NO3-; n = 0, 2), Ni(L1-2)H2O. The composition and structure of these compounds were determined using elemental analysis, magnetochemical research and IR-spectroscopy. It was determined that all coordination compounds have monomeric structure. The thiosemicarbazones H2L1-2 act as tridentate ligands with O, N, S set of donor atoms. Synthesized coordination compounds show selective antimicrobial activity towards a series of standard strains of Staphylococcus aureus, Escherihia coli, and Candida albicans in the range of concentration 0.0039-0.5 mg/mL. It was shown that the nature of the central atom has a main influence on the antimicrobial activity of these complexes. For the homotypic complexes the activity diminishes in the following way: Cu > Ni > Co ≥ Fe. The nature of thiosemicarbazone and acid residue also has an influence on antimicrobial activity. The antimicrobial activity reduces in the following way: H2L1 > H2L2 and NO3- > ClO4-> Cl- ≥ Br-. Synthesized compounds manifest the best activity towards the standard strains of Staphylococcus aureus and Candida albicans.

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