Biological Evaluation of a Series of Amine-Containing Mixed-Ligand Copper(II) Coordination Compounds with 2-(2-hydroxybenzylidene)-N-(prop-2-en-1-yl)hydrazinecarbothioamide

Gulya Aurelian; Toderash Ion; Garbuz Olga; Ulchina Ianina; Graur Vasilii О.; Railyan Nadejda

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GULYA, Aurelian, TODERASH, Ion, GARBUZ, Olga, ULCHINA, Ianina, GRAUR, Vasilii О., RAILYAN, Nadejda. Biological Evaluation of a Series of Amine-Containing Mixed-Ligand Copper(II) Coordination Compounds with 2-(2-hydroxybenzylidene)-N-(prop-2-en-1-yl)hydrazinecarbothioamide. In: Microscopy and Microanalysis, 2022, vol. 28, pp. 1696-1702. ISSN 1431-9276. DOI: https://doi.org/10.1017/S1431927622000733

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Microscopy and Microanalysis

Volumul 28 / 2022 / ISSN 1431-9276 /ISSNe 1435-8115

Biological Evaluation of a Series of Amine-Containing Mixed-Ligand Copper(II) Coordination Compounds with 2-(2-hydroxybenzylidene)-N-(prop-2-en-1-yl)hydrazinecarbothioamide

DOI:https://doi.org/10.1017/S1431927622000733

Pag. 1696-1702

Gulya Aurelian¹, Toderash Ion², Garbuz Olga¹², Ulchina Ianina¹, Graur Vasilii О.¹, Railyan Nadejda²

¹ Moldova State University,
² Institute of Zoology

Disponibil în IBN: 16 ianuarie 2024

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Rezumat

Five compounds 2-(2-hydroxybenzylidene)-N-(prop-2-en-1-yl)hydrazinecarbothioamide (H2L), bis[2-2-({2-[(prop-2-en-1-yl)carbamothioyl]hydrazinylidene}methyl)phenolato-S,N,O:O]diaquadicopper(II) nitrate (1), bis[2-2-({2-[(prop-2-en-1-yl)carbamothioyl]hydrazinylidene}methyl)phenolato-S,N,O:O]diimidazoldicopper(II) nitrate (2), bis[2-2-({2-[(prop-2-en-1-yl)carbamothioyl]-hydrazinylidene}methyl)phenolato-S,N,O:O]bis-(3,5-dibromopyridine)dicopper(II) nitrate (3), bis[2-2-({2-[(prop-2-en-1-yl)carbamothioyl]-hydrazinylidene}methyl)phenolato-S,N,O:O]bis(4-methylpyridine)dicopper(II) nitrate hexahydrate (4) were synthesized. The antiproliferative properties of these compounds toward cancer cell lines RD, HeLa, and normal cell line MDCK have been investigated. The tested complexes surpass Doxorubicin (DOXO) in the efficiency of anticancer activity as their IC50 values toward cancer cells are lower than the corresponding values of DOXO and the selectivity indexes exceed the corresponding SI value of DOXO. The tested compounds demonstrated a high antioxidant effect against ABTS•+ radical cations as well as low toxicity on Daphnia magna.

Cuvinte-cheie
anticancer compound, antioxidant activity, antiproliferative activity, selective activity, toxicity

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