The present study presents the results of the separate action of low temperature of a moderate stress intensity and its joint action with sound on some indices of the natural resistance and adaptive capacities of calves in the early postnatal ontogeny, carried out in order to determine the parameters that can be used as a stimulus in beneficial conditioning of homeostasis, resistance and adaptive capacities of animals to the action of environmental factors. Thus, it has been determined that the value of the phagocytic activity in calves from the experimental groups in both experimental series is higher compared to its value in the reference groups. The same development dynamics is also demonstrated by the bactericidal activity. Lysozyme increases both in the experimental group in which temperature was applied (EGT) and in the experimental group in which temperature and sound were applied (EGTS), but in EGTS this increase is more uniform. Cortisol increases dynamically towards the 30th day in the experimental groups, but in EGTS its increase is more obvious than in EGT. As a result of the solitary application of the thermal factor of a moderate stress intensity on the body of the calves, a beneficial action regarding the body weight is recorded throughout the study period (27 days) compared to the reference group and it was 6.0 kg, which corresponds to 222 g daily gain. Following the combined application of the low temperature with the sound of a moderate stress intensity on the body of the calves, a beneficial increase in the body mass of the calves from the experimental group compared to the reference group is initially observed, which subsequently decreases and at the age of 30 days the body weight of the calves from the experimental group is lower than the weight of the reference group calves. Thus, we can note that the combined action of low temperature and sound of a moderate stress intensity on calves in the early postnatal period has a beneficial effect on some indices of natural resistance such as phagocytic activity, bactericidal activity and lysozyme, but does not have a beneficial effect on body mass growth (a quantitative index of productivity).