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Ultima descărcare din IBN: 2024-04-04 13:51 |
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544.142.3:546.562:547.497.1 (1) |
Structura chimică a materiei (98) |
Chimie anorganică (450) |
Chimie organică (484) |
SM ISO690:2012 GRAUR, Vasilii О., GRAUR, Ianina, GULYA, Aurelian, TELEUCĂ, Iulia, LOZAN-TYRSHU, K., BALAN, Greta. Copper(II) coordination compounds with 2-acetylpyridine N4-(bicyclo[2.2.1]heptan-2-yl)thiosemicarbazone as potential antibacterial agents. In: Studia Universitatis Moldaviae (Seria Ştiinţe Reale şi ale Naturii), 2023, nr. 1(171), pp. 206-213. ISSN 1814-3237. DOI: https://doi.org/10.59295/sum1(171)2023_27 |
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Studia Universitatis Moldaviae (Seria Ştiinţe Reale şi ale Naturii) | |||||||
Numărul 1(171) / 2023 / ISSN 1814-3237 /ISSNe 1857-498X | |||||||
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DOI:https://doi.org/10.59295/sum1(171)2023_27 | |||||||
CZU: 544.142.3:546.562:547.497.1 | |||||||
Pag. 206-213 | |||||||
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The paper presents the synthesis of the new 2-acetylpyridine N4-(bicyclo[2.2.1]hept-2-yl)thiosemicarbazone (HL) and its three copper(II) coordination compounds: [Cu(L)X] (X = NO3 - (I), Cl- (II), CHCl2COO- (III)). The obtained compounds were studied by NMR and FTIR spectroscopies, elemental analysis, and molar electric conductibility. The antibacterial activity towards Gram-positive (Staphylococcus aureus, Bacillus cereus) and Gram-negative (Escherichia coli, Acinetobacter baumannii) standard strains was studied for the HL and complexes I-III. The coordination of the HL to the copper(II) atom leads to the increase of activity against almost all microorganisms. Complex I is the most active one towards Gram-positive microorganisms, while complex III is the most active one towards Gram-negative microorganisms. They in many cases surpass the activity of Furacillinum and are practically on the same level as Tetracycline towards Gram-positive microorganisms. |
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Cuvinte-cheie Thiosemicarbazones, coordination compounds, copper, antibacterial activity, tiosemicarbazone, compuşi coordinativi, cupru, activitate antibacteriană |
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