Conţinutul numărului revistei |
Articolul precedent |
Articolul urmator |
196 0 |
SM ISO690:2012 CONSTANTIN, Olga, CĂLCÎI, Cornelia, FEGHIU, Ludmila, CALISTRU, Iulia, CALISTRU, Andrei, HADJIU, Svetlana. Neurological manifestations associated with Sars-CoV-2 infection in children. In: Revista de Ştiinţe ale Sănătăţii din Moldova, 2022, nr. 3 An.1(29), p. 401. ISSN 2345-1467. |
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Revista de Ştiinţe ale Sănătăţii din Moldova | ||||||
Numărul 3 An.1(29) / 2022 / ISSN 2345-1467 | ||||||
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Pag. 401-401 | ||||||
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Background. Understanding of COVID-19 is evolving and neurological manifestations are found in more than 1/3 of cases of SARS-Cov-2 infection. Actually, acute epileptic seizures and SE in children currently demonstrate a high mortality rate (between 5% and 39%) in combination and post-infection SARS-CoV-2. Objective of the study. To estimate the prevalence of the association of neurological manifestations, including acute seizures and status epilepticus (SE) after infection with Covid-19 in children. Material and methods. Prospective study was conducted on a group of 74 children with age reference from 6 months to 10 years, who were hospitalized in the Neurology Department and IMSP Mother and Child Institute and selected according to the association of neurological symptoms especially those who associated SE during and after infection with Covid-19. Examinations: EEG, imaging. The SPSS program was used for statistical analysis. Results. Seizures and SE have been reported at 36.1% cases with COVID-19, 40% had no history of epilepsy, 10% have been presenting primary symptom seizures. Within, other acute neurologic manifestations were meningoencephalitis (41.1%), ADEM (8.1%), Kawasaki disease (8.01%), stroke (23.4%), myositis (21.6%). In addition, neurologic symptoms reported in case series to persist after COVID-19 infection include headache (21,7%), anosmia/dysgeusia (18,4%), cognitive dysfunction (22.1%), sleep impairments (17.1%). EEG findings and imaging data correlated with cerebral distress (r = 0.62), (r = 0.78), respectively. No significant difference was noticed between the recurrence of in-hospital (p> 0.01) and out-of-hospital SE (p > 0.02). Conclusions. The neurotropism of the virus predisposes the child’s brain, which has different properties to the adult, to severe neurological complications such as epileptic seizures and SE. High levels of circulating cytokines and hyperactivation of immune cells lead to systemic inflammatory syndrome, with direct or indirect damage to the CNS. |
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Cuvinte-cheie epilepsy, status epilepticus, SARS-CoV-2 infection, COVID-19, manifestări neurologice, crize epileptic, status epileptic, SARS-CoV-2, COVID-19 |
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