Conţinutul numărului revistei |
Articolul precedent |
Articolul urmator |
206 3 |
Ultima descărcare din IBN: 2023-07-04 11:02 |
SM ISO690:2012 DOLAPCIU, Elena, REVENCO, Ninel, ANDRIESH, Lucia P., LEURDA, Veronica. Immunity screening in children with signs suggestive of primary immunodeficiency. In: Revista de Ştiinţe ale Sănătăţii din Moldova, 2022, nr. 3 An.1(29), p. 402. ISSN 2345-1467. |
EXPORT metadate: Google Scholar Crossref CERIF DataCite Dublin Core |
Revista de Ştiinţe ale Sănătăţii din Moldova | ||||||
Numărul 3 An.1(29) / 2022 / ISSN 2345-1467 | ||||||
|
||||||
Pag. 402-402 | ||||||
|
||||||
Descarcă PDF | ||||||
Rezumat | ||||||
Background. Primary immunodeficiency (PID) diseases are a diverse group of rare genetic disorders that affect the development and/or function of the immune system. Early detection of PID is important for timely intervention. The warning signs of primary immunodeficiency in children are a family history of primary immunodeficiency, failure to gain weight or grow normally, four or more new ear infections within one year, six or more acute viral respiratory infections within one year, two or more deep-seated infections including septicemia, deep skin or organ abscesses, two or more months on antibiotics with little effect recurrent, persistent fungal infection on skin, recurrent diarrhea. Objective of the study. The objective of this study was to test the validity of the warning signs in identifying PID in children. Material and Methods. We conducted a cross sectional study that included 30 children presenting with clinical history and/or features suggestive of immunodeficiency. Patient’s ages ranged between 0.5-14 years, median 5.2 years. They were subjected to clinical evaluation, measurement of serum immunoglobulin (Ig) levels and test for cellular immunity. Results. Recurrent respiratory infections were the most common manifestation (83%), 23% patients had failure to thrive, 9% patients -deep-seated infections including septicemia, 6%-patients- recurrent abscesses. According to immunological evaluation, 18 children (60%) had signs of immunodeficiency: 7 patients (13%) had combined immunodeficiency, 12 patients had disimmunoglobulinemia (hypoIgM - 17%, hypoIgG - 17%, hypoIgA - 7%, hyperIgE - 13%) and 5 (17%) had hypogammaglobulinemia. Decreased CD19 levels and immunoregulatory index were identified in 30% of cases. Conclusion. The selection of children according to warning signs for PID made it possible to identify signs of PID in 60% of children. Humoral deficiencies were most often detected (70% of all cases). |
||||||
Cuvinte-cheie primary immunodeficiency, children, warning signs, imunodeficiență primară, copii, semne sugestive |
||||||
|