| Articolul precedent |
| Articolul urmator |
 |
 306 13 |
| Ultima descărcare din IBN: 2023-09-28 14:21 |
| Căutarea după subiecte similare conform CZU |
| 547.947 (2) |
| Chimie organică (484) |
 SM ISO690:2012RUSNAC, Anna, GARBUZ, Olga, SHOVA, Sergiu, GULYA, Aurelian. Copper complexes with N4(2-ethyl benzoate) thiosemicarbazone of 2-acetylpyridine. In: Life sciences in the dialogue of generations: connections between universities, academia and business community, Ed. 2, 29-30 septembrie 2022, Chişinău. Chișinău, Republica Moldova: Moldova State University, 2022, p. 223. ISBN 978-9975-159-80-7. |
| EXPORT metadate: Google Scholar Crossref CERIF DataCite Dublin Core |
| Life sciences in the dialogue of generations: connections between universities, academia and business community 2022 | ||||||
|
Conferința "Life sciences in the dialogue of generations: connections between universities, academia and business community" 2, Chişinău, Moldova, 29-30 septembrie 2022 | ||||||
|
||||||
| CZU: 547.947 | ||||||
| Pag. 223-223 | ||||||
|
||||||
 Descarcă PDF |
||||||
| Rezumat | ||||||
Thiosemicarbazones are an important class of organic compounds that have attracted attention in the pharmaceutical industry due to their high biological activity such as antibacterial, antifungal, antiviral, antimalarial, antitumor and others. The paper presents the synthesis of new ligand and coordination compounds of Cu(II), with N4(2-ethyl benzoate) thiosemicarbazone of 2-acetilpyridine (3) obtained through the addition of ethyl 2-isothiocyanatobenzoate (2) with 2(1-hydrazinylideneethyl)pyridine. 1 CSCl 2, NaHCO 3 COOC2H5 NH2 H5C2OOC S C N H2N N CH3 N H3C H5C2OOC NH N S NH N 2 3 (noted by HL) Fig. 1. Synthesis of N4(2-ethyl benzoate) thiosemicarbazone of 2-acetilpyridine (3) Based on the synthesized thiosemicarbazone HL, five coordination compounds were obtained by mixing, the salts of Cu(II) solutions in ethanol and ligand solutions in ethanol ratio of 1:1, reflux for half an hour. Obtained as a green microcrystalline complexes according to the reaction written below. HL + CuX2 · nH2O = {Cu(L)X} + nH2O +HX (1) X=Cl-, NO3 -, CH3COO-, ClO4 -; n=0-6. (2) The characterization of new compounds was done by 1H NMR, 13C NMR, IR spectroscopy, conductivity and elemental analysis. In addition, the structures of the ligand (HL) and complexes [Cu(L)NO3], [Cu(L)H2O]2‧2ClO4‧4H2O were determined by single-crystal X-ray diffraction. Fig. 2. Crystalline structure of ligand (HL), coordination compound [Cu(L)NO3] and [Cu(L)H2O]2‧2ClO4‧4H2O The effect of ligand and complexes on antioxidant activity were studied. The best result was found to be on ligand, with IC50 = 22.51 μM, it is better than the substance Trolox, IC50 =33.33 μM used in medicine. |
||||||
| Cuvinte-cheie antioxidant activity, Thiosemicarbazones, IR spectroscopy, ligand. |
||||||
|
Dublin Core Export
<?xml version='1.0' encoding='utf-8'?>
<oai_dc:dc xmlns:dc='http://purl.org/dc/elements/1.1/' xmlns:oai_dc='http://www.openarchives.org/OAI/2.0/oai_dc/' xmlns:xsi='http://www.w3.org/2001/XMLSchema-instance' xsi:schemaLocation='http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd'>
<dc:creator>Rusnac, A.G.</dc:creator>
<dc:creator>Garbuz, O.S.</dc:creator>
<dc:creator>Şova, S.G.</dc:creator>
<dc:creator>Gulea, A.P.</dc:creator>
<dc:date>2022</dc:date>
<dc:description xml:lang='en'><p>Thiosemicarbazones are an important class of organic compounds that have attracted attention in the pharmaceutical industry due to their high biological activity such as antibacterial, antifungal, antiviral, antimalarial, antitumor and others. The paper presents the synthesis of new ligand and coordination compounds of Cu(II), with N4(2-ethyl benzoate) thiosemicarbazone of 2-acetilpyridine (3) obtained through the addition of ethyl 2-isothiocyanatobenzoate (2) with 2(1-hydrazinylideneethyl)pyridine. 1 CSCl 2, NaHCO 3 COOC2H5 NH2 H5C2OOC S C N H2N N CH3 N H3C H5C2OOC NH N S NH N 2 3 (noted by HL) Fig. 1. Synthesis of N4(2-ethyl benzoate) thiosemicarbazone of 2-acetilpyridine (3) Based on the synthesized thiosemicarbazone HL, five coordination compounds were obtained by mixing, the salts of Cu(II) solutions in ethanol and ligand solutions in ethanol ratio of 1:1, reflux for half an hour. Obtained as a green microcrystalline complexes according to the reaction written below. HL + CuX2 · nH2O = {Cu(L)X} + nH2O +HX (1) X=Cl-, NO3 -, CH3COO-, ClO4 -; n=0-6. (2) The characterization of new compounds was done by 1H NMR, 13C NMR, IR spectroscopy, conductivity and elemental analysis. In addition, the structures of the ligand (HL) and complexes [Cu(L)NO3], [Cu(L)H2O]2‧2ClO4‧4H2O were determined by single-crystal X-ray diffraction. Fig. 2. Crystalline structure of ligand (HL), coordination compound [Cu(L)NO3] and [Cu(L)H2O]2‧2ClO4‧4H2O The effect of ligand and complexes on antioxidant activity were studied. The best result was found to be on ligand, with IC50 = 22.51 μM, it is better than the substance Trolox, IC50 =33.33 μM used in medicine.</p></dc:description>
<dc:source>Life sciences in the dialogue of generations: connections between universities, academia and business community () 223-223</dc:source>
<dc:subject>antioxidant activity</dc:subject>
<dc:subject>Thiosemicarbazones</dc:subject>
<dc:subject>IR spectroscopy</dc:subject>
<dc:subject>ligand.</dc:subject>
<dc:title>Copper complexes with N4(2-ethyl benzoate) thiosemicarbazone of 2-acetylpyridine</dc:title>
<dc:type>info:eu-repo/semantics/article</dc:type>
</oai_dc:dc>|
|
|
