Promotion of the natural wines with reduced alcohol degree for the young people, elders and for people with health problems as well as substitution of soft beverages obtained by adding of preservatives, colourants and flavoring substances is one of global winemaking trends taken by the Republic of Moldova. Wine partially dealcoholized is a product obtained by partial dealcoholization of dry wine by eliminating of the alcohol from wine using physical separation processes. The process of dealcoholization was carried in laboratory conditions using rotary evaporator. Dealcoholization process depends on different physical parameters one of which is pressure. Hence, the influence of pressure on physical and chemical parameters of obtained wines by distillation under vacuum was studied.