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SM ISO690:2012 ROMANCIUC (VENGHER), Inna, DUMBRAVA, Vlada-Tatiana, LUPAŞCO, Iulianna, HAREA, Gheorghe, CHIRVAS, Elena. Biological and psychogenic mechanisms of depression in patients with chronic viral hepatitis . In: Journal of Gastrointestinal and Liver Diseases, 2016, nr. S2(25), pp. 27-28. ISSN 1841-8724. |
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Journal of Gastrointestinal and Liver Diseases | ||||||
Numărul S2(25) / 2016 / ISSN 1841-8724 /ISSNe 1842-1121 | ||||||
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Pag. 27-28 | ||||||
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Introduction: Depression in patients with chronic viral hepatitis (ChVH) occurs due to the interaction of biological and psychogenic mechanisms. Scope: To study the role of psychogenic and biological factors (cytolysis enzymes, serotonin metabolism parameters, circulating immune complexes) associated with depression in patients with ChVH. Material and methods:147 patients with ChVH B, C, D without antiviral treatment, of which 63 (42.86%) females and 84 (57.14%) males, average age 37.29 ± 0.89 years. We measured depressive scores using the Hamilton Rating Scale for Depression (HDRS-21). Laboratory tests to evaluate the activity of transaminases (ALT≤2N or ALT>2N), the peripheral level of serotonin (Ser) and tryptophan (Try) and concentration of circulating immune complexes (CIC) were performed. All the parameters were compared to those of the control group (CG) - 29 healthy people. Results: We found a higher prevalence of asthenic, digestive, and pain symptoms after detection of ChVH compared to the period prior to diagnosis. Depressive scores were detected in 85.03% (125) of patients with ChVH in comparison to healthy people 13.79% in CG (p<0.001). Non-depressed patients had values of Ser and Try similar to those of CG. The lowest values of Ser (p <0.001) and Try (p <0.001) were determined in patients with moderate-to-severe depression versus mild depression. In patients with ALT≤2N (n=64) serotonin and tryptophan were higher (p<0.05 and p <0.05) versus ChVH with ALT> 2N (N = 83). CIC were increased in ChVH versus CG (p <0.001), and in depressive versus non-depressive patients (p <0.001), in severe depression versus mild depression (p <0.05). Conclusions: The semantics of diagnosis is a psychogenic factor that contributes to depression in people with detected ChVH. Psychosomatic interactions involve the serotonin system, influenced by the immune system and hepatocytolytic activity. |
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