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Ultima descărcare din IBN: 2024-01-28 00:40 |
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576.3:591453.1 (1) |
Biologie celulară și subcelulară. Citologie (130) |
Zoologie generală (265) |
SM ISO690:2012 BALAN, Ion, ROŞCA, Nicolae, BUZAN, Vladimir, FIODOROV, Nicolai, DUBALARI, Alexandru, BLYNDU, Irina, CREŢU, Roman. The biological role of apoptosis in spermatogenesis: a review. In: Oltenia - studii si comunicari stiintele naturii, 2020, nr. 2(36), pp. 137-145. ISSN 1454-6914. |
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Oltenia - studii si comunicari stiintele naturii | |||||||
Numărul 2(36) / 2020 / ISSN 1454-6914 | |||||||
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CZU: 576.3:591453.1 | |||||||
Pag. 137-145 | |||||||
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Apoptosis as a fundamental biological phenomenon is a special, genetically programmed form of physiological death of cell and is a prerequisite for the development and normal reproduction of living biodiversity, in particular the functioning of the reproductive system and the regulation of spermatogenesis. Apoptosis plays an important role in the regulation of spermatogenesis, a complex multi-stage process of sperm formation from primary germ cells, which begins during puberty and lasts throughout. The role of apoptosis in the regulation of spermatogenesis is well determined, since it controls the number of germ cells and eliminates defective gametes, but the role of apoptosis in ejaculate fertility impairment has not been elucidated yet. The biological role of apoptosis mechanisms in spermatogenesis is to maintain a constant number of cells in the spermatogenic system, to ensure the correct ratio of cells of various types and to remove genetically defective cells. Apoptotic changes in spermatozoa may result from the process initiated during spermatogenesis due to genetic disorders. So, a distortion of chromosome segregation, fixed at the verification points of the cell cycle, can lead to a switch to the apoptosis pathway. Thus, on the basis of the synthesis of information, it can be concluded that the biological role of apoptosis in the regulation of spermatogenesis is huge and inevitable for preserving biodiversity, however, to date, the patterns of sperm cell apoptosis realization and apoptosis markers initiation in the process have not been completely clarified. At the same time, it has been shown that the regulation of sperm cell apoptosis is directly dependent on the influence of various factors; in particular, it depends on the properties, concentration and time of exposure of the damaging agent to spermatogenesis. |
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Cuvinte-cheie apoptosis, spermatogenesis, biodiversity, spermatogenic system, apoptoză, spermatogeneză, biodiversitate, sistemul spermatogen |
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