Synthesis, Structure, and Biological Activity of Copper(II), Nickel(II), Cobalt(III), and Iron(III) Coordination Compounds with 2-{2-[(Prop-2-en-1-yl)carbamothioyl]hydrazinylidene}propanoic Acid
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GULEA, Aurelian; GRAUR, Vasilii О.; DIURICI, E.; ULCHINA, Ianina; BOUROSH, Pavlina; BALAN, Greta; BURDUNIUC, Olga; TSAPKOV, Victor I.; RUDIC, Valeriu. Synthesis, Structure, and Biological Activity of Copper(II), Nickel(II), Cobalt(III), and Iron(III) Coordination Compounds with 2-{2-[(Prop-2-en-1-yl)carbamothioyl]hydrazinylidene}propanoic Acid. In: Russian Journal of General Chemistry. 2020, nr. 11(90), pp. 2120-2127. ISSN 1070-3632.
10.1134/S107036322011016X
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Russian Journal of General Chemistry
Numărul 11(90) / 2020 / ISSN 1070-3632

Synthesis, Structure, and Biological Activity of Copper(II), Nickel(II), Cobalt(III), and Iron(III) Coordination Compounds with 2-{2-[(Prop-2-en-1-yl)carbamothioyl]hydrazinylidene}propanoic Acid


DOI: 10.1134/S107036322011016X
Pag. 2120-2127

Gulea Aurelian1, Graur Vasilii О.1, Diurici E.1, Ulchina Ianina1, Bourosh Pavlina2, Balan Greta3, Burduniuc Olga34, Tsapkov Victor I.1, Rudic Valeriu5
 
1 State University of Moldova,
2 Institute of Applied Physics,
3 ”Nicolae Testemițanu” State University of Medicine and Pharmacy,
4 National Agency for Public Health,
5 Institute of Microbiology and Biotechnology
 
Disponibil în IBN: 29 decembrie 2020


Rezumat

2-Oxopropanoic acid reacts in ethanol with N-(prop-2-en-1-yl)hydrazinecarbothioamide in a 1 : 1 mole ratio to form thiosemicarbazone H2L. Coordination compounds Cu(HL)X [X = Cl, Br, NO3], Cu(H2O)(L), Ni(HL)2, Co(HL)2X [X = Cl, Br], and Fe(HL)2X [X = NO3, Br] are formed in the reactions of H2L with copper(II), nickel(II), cobalt(II), and iron(III) salts. The reactions of Cu(H2O)(L) with imidazole (Im) and 3,4-dimethylpyridine (3,4-Lut) result in mixed-ligand complexes Cu(A)(L) [A = Im, 3,4-Lut]. The structures of two copper complexes were determined by single crystal X-ray diffraction analysis. The synthesized complexes exhibit selective antimicrobial and antifungal activity in the concentration range of 15.62–1000 μg/mL. The introduction of amines into the inner sphere of copper complexes leads to an increase in the antimicrobial activity. 

Cuvinte-cheie
Antifungal activity, Antimicrobial activity, coordination compounds, pyruvic acid 4-allylthiosemicarbazone