Synthesis, Structure, and Biological Activity of Copper(II), Nickel(II), Cobalt(III), and Iron(III) Coordination Compounds with 2-{2-[(Prop-2-en-1-yl)carbamothioyl]hydrazinylidene}propanoic Acid
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GULYA, Aurelian, GRAUR, Vasilii О., DIURICI, E., ULCHINA, Ianina, BOUROSH, Pavlina, BALAN, Greta, BURDUNIUC (POPA), Olga, TSAPKOV, Victor I., RUDIK, V.. Synthesis, Structure, and Biological Activity of Copper(II), Nickel(II), Cobalt(III), and Iron(III) Coordination Compounds with 2-{2-[(Prop-2-en-1-yl)carbamothioyl]hydrazinylidene}propanoic Acid. In: Russian Journal of General Chemistry, 2020, vol. 90, pp. 2120-2127. ISSN 1070-3632. DOI: https://doi.org/10.1134/S107036322011016X
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Russian Journal of General Chemistry
Volumul 90 / 2020 / ISSN 1070-3632 /ISSNe 1608-3350

Synthesis, Structure, and Biological Activity of Copper(II), Nickel(II), Cobalt(III), and Iron(III) Coordination Compounds with 2-{2-[(Prop-2-en-1-yl)carbamothioyl]hydrazinylidene}propanoic Acid

DOI: https://doi.org/10.1134/S107036322011016X

Pag. 2120-2127

Gulya Aurelian1, Graur Vasilii О.1, Diurici E.1, Ulchina Ianina1, Bourosh Pavlina2, Balan Greta3, Burduniuc (Popa) Olga34, Tsapkov Victor I.1, Rudik V.5
 
1 Moldova State University,
2 Institute of Applied Physics,
3 ”Nicolae Testemițanu” State University of Medicine and Pharmacy,
4 National Agency for Public Health,
5 Institute of Microbiology and Biotechnology
 
Proiecte:
 
Disponibil în IBN: 29 decembrie 2020


Rezumat

2-Oxopropanoic acid reacts in ethanol with N-(prop-2-en-1-yl)hydrazinecarbothioamide in a 1 : 1 mole ratio to form thiosemicarbazone H2L. Coordination compounds Cu(HL)X [X = Cl, Br, NO3], Cu(H2O)(L), Ni(HL)2, Co(HL)2X [X = Cl, Br], and Fe(HL)2X [X = NO3, Br] are formed in the reactions of H2L with copper(II), nickel(II), cobalt(II), and iron(III) salts. The reactions of Cu(H2O)(L) with imidazole (Im) and 3,4-dimethylpyridine (3,4-Lut) result in mixed-ligand complexes Cu(A)(L) [A = Im, 3,4-Lut]. The structures of two copper complexes were determined by single crystal X-ray diffraction analysis. The synthesized complexes exhibit selective antimicrobial and antifungal activity in the concentration range of 15.62–1000 μg/mL. The introduction of amines into the inner sphere of copper complexes leads to an increase in the antimicrobial activity. 

Cuvinte-cheie
Antifungal activity, Antimicrobial activity, coordination compounds, pyruvic acid 4-allylthiosemicarbazone