In this scientific article I will analyse the regionalization process of the Republic of Moldova adapted through the ecological agro-food commerce, which in their turn represent the good safety and it is the consumer’s major demand of European Union.European markets ask strictly that the agro-food products being not only qualitative, but also inoffensive for their health. The fact is proved by the existence of 80000 of fresh fruit and vegetable producer from 80 countries, GLOBALGAP certificated, which realize export operations in the European Union Countries, the certification according the HACCP and ISO, standards are also recognized systems in the food stuff industry as efficient approaches in getting qualitative products, in assuring the appropriate hygiene and some production technique witch will bat, in the end, to an appropriate safety of food products. In the republic of Moldova over 100 enterprises had been certified according to the ISO international standards demands, the certification becoming a special demand for the realization of export operations and for the development of the relations with prestigious partners.