| Conţinutul numărului revistei |
| Articolul precedent |
| Articolul urmator |
 181 0 |
 SM ISO690:2012JENKINS, Helen Elizabeth, PLEŞCA, Valeriu, CIOBANU, Anisoara, KRUDU, V., GALUSCA, Irina, SOLTAN, Viorel, SERBULENCO, Aliona, ZIGNOL, Matteo, DADU, Andrei, MASOUD, Dara, COHEN, Ted. Assessing spatial heterogeneity of multidrug-resistant tuberculosis in a high-burden country. In: European Respiratory Journal, 2013, vol. 42, pp. 1291-1301. ISSN 0903-1936. DOI: https://doi.org/10.1183/09031936.00111812 |
| EXPORT metadate: Google Scholar Crossref CERIF DataCite Dublin Core |
  European Respiratory Journal |
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| Volumul 42 / 2013 / ISSN 0903-1936 /ISSNe 1399-3003 | |
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| DOI:https://doi.org/10.1183/09031936.00111812 | |
| Pag. 1291-1301 | |
| Rezumat | |
Multidrug-resistant tuberculosis (MDR-TB) is a major concern in countries of the former Soviet Union. The reported risk of resistance among tuberculosis (TB) cases in the Republic of Moldova is among the highest in the world. We aimed to produce high-resolution spatial maps of MDR-TB risk and burden in this setting. We analysed national TB surveillance data collected between 2007 and 2010 in Moldova. High drug susceptibility testing coverage and detailed location data permitted identification of subregional areas of higher MDR-TB risk. We investigated whether the distribution of cases with MDR-TB risk factors could explain this observed spatial variation in MDR-TB. 3447 MDR-TB cases were notified during this period; 24% of new and 62% of previously treated patients had MDR-TB. Nationally, the estimated annual MDR-TB incidence was 54 cases per 100 000 persons and >1000 cases per 100 000 persons within penitentiaries. We identified substantial geographical variation in MDR-TB burden and hotspots of MDR-TB. Locations with a higher percentage of previously incarcerated TB cases were at greater risk of being MDR-TB hotspots. Spatial analyses revealed striking geographical heterogeneity of MDR-TB. Methods to identify locations of high MDR-TB risk and burden should allow for better resource allocation and more appropriate targeting of studies to understand local mechanisms driving resistance |
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| Cuvinte-cheie MeSH Adolescent, adult, Aged, Antitubercular Agents, Area Under Curve, child, child, preschool, Epidemiological Monitoring, geography, Humans, infant, infant, newborn, Logistic Models, middle aged, Moldova, prisoners, public health, risk factors, tuberculosis, Multidrug-Resistant, Young Adult EMTREE drug terms isoniazid, rifampicin EMTREE medical terms area under the curve, article, bacterium culture, disease surveillance, education, geography, human, incidence, lung tuberculosis, Moldova, Multidrug Resistant Tuberculosis, priority journal, prison, receiver operating characteristic, risk assessment, risk factor, sex difference, smear, tuberculosis control, USSR |
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