The influence of CIS-methyl 5'-chloro-2'-oxospiro[cyclopropane-1,3'-indoline]-2-carboxylate on the activity of some phytophotogenic viruses
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SUCMAN, Natalia; CEBANU, Vitalie; TERTEAC, Dumitru; ARMAŞU, Svetlana; MACAEV, Fliur. The influence of CIS-methyl 5'-chloro-2'-oxospiro[cyclopropane-1,3'-indoline]-2-carboxylate on the activity of some phytophotogenic viruses. In: Achievements and perspectives of modern chemistry. 9-11 octombrie 2019, Chişinău. Chisinau, Republic of Moldova: Tipografia Academiei de Ştiinţe a Moldovei, 2019, p. 227. ISBN 978-9975-62-428-2.
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Achievements and perspectives of modern chemistry 2019
Conferința "International Conference "Achievements and perspectives of modern chemistry""
Chişinău, Moldova, 9-11 octombrie 2019

The influence of CIS-methyl 5'-chloro-2'-oxospiro[cyclopropane-1,3'-indoline]-2-carboxylate on the activity of some phytophotogenic viruses


Pag. 227-227

Sucman Natalia12, Cebanu Vitalie3, Terteac Dumitru3, Armaşu Svetlana3, Macaev Fliur1
 
1 Institute of Chemistry,
2 Comrat State University,
3 Research Institute for Horticulture and Alimentary Technologies
 
Disponibil în IBN: 12 noiembrie 2019


Rezumat

The unique structural features of spirooxindoles together with the diverse biological activities have made them privileged structures in new drug discovery. According to a large number of publications, such spiro compounds have different biological properties [1]. Among them are activities against numerous viruses. Previously, we and other authors have reported about spiro compounds that can potentially be used as anti-HIV agents, or in veterinary medicine against Bovine Viral Diarrhoea Virus (BVDV) [2,3,4]. Nowadays, compound 1 is being tested for its ability to inhibit the action of the tobacco mosaic virus- TMV, tomato spotted wilt virus-TSWV and cucumber mosaic virus-CMV.formulaTSWV infects a variety of hosts, contributing to its global economic impact on crops. There are over a thousand of different hosts for TSWV. The host range of TSWV includes economically important crops like tomatoes and tobacco. TMV is known as one of the most stable viruses. It has a very wide survival range. As long as the surrounding temperature remains below approximately 40 degrees Celsius, TMV can sustain its stable form. The effect of the tested compoundsagainst TSWV is studied on the tomatoes of Emir variety. Studies on the effects of the same compounds against CMV are conducted on Rodnichok cucumbers. The effect of the preparations is also tested under conditions of artificial infection of the susceptible variety of tomatoes Elvira with the TMV under controlled conditions (in the climate chamber-POL-ECO-APARAT).

The unique structural features of spirooxindoles together with the diverse biological activities have made them privileged structures in new drug discovery. According to a large number of publications, such spiro compounds have different biological properties [1]. Among them are activities against numerous viruses. Previously, we and other authors have reported about spiro compounds that can potentially be used as anti-HIV agents, or in veterinary medicine against Bovine Viral Diarrhoea Virus (BVDV) [2,3,4]. Nowadays, compound 1 is being tested for its ability to inhibit the action of the tobacco mosaic virus- TMV, tomato spotted wilt virus-TSWV and cucumber mosaic virus-CMV.formulaTSWV infects a variety of hosts, contributing to its global economic impact on crops. There are over a thousand of different hosts for TSWV. The host range of TSWV includes economically important crops like tomatoes and tobacco. TMV is known as one of the most stable viruses. It has a very wide survival range. As long as the surrounding temperature remains below approximately 40 degrees Celsius, TMV can sustain its stable form. The effect of the tested compoundsagainst TSWV is studied on the tomatoes of Emir variety. Studies on the effects of the same compounds against CMV are conducted on Rodnichok cucumbers. The effect of the preparations is also tested under conditions of artificial infection of the susceptible variety of tomatoes Elvira with the TMV under controlled conditions (in the climate chamber-POL-ECO-APARAT).

The unique structural features of spirooxindoles together with the diverse biological activities have made them privileged structures in new drug discovery. According to a large number of publications, such spiro compounds have different biological properties [1]. Among them are activities against numerous viruses. Previously, we and other authors have reported about spiro compounds that can potentially be used as anti-HIV agents, or in veterinary medicine against Bovine Viral Diarrhoea Virus (BVDV) [2,3,4]. Nowadays, compound 1 is being tested for its ability to inhibit the action of the tobacco mosaic virus- TMV, tomato spotted wilt virus-TSWV and cucumber mosaic virus-CMV.formulaTSWV infects a variety of hosts, contributing to its global economic impact on crops. There are over a thousand of different hosts for TSWV. The host range of TSWV includes economically important crops like tomatoes and tobacco. TMV is known as one of the most stable viruses. It has a very wide survival range. As long as the surrounding temperature remains below approximately 40 degrees Celsius, TMV can sustain its stable form. The effect of the tested compoundsagainst TSWV is studied on the tomatoes of Emir variety. Studies on the effects of the same compounds against CMV are conducted on Rodnichok cucumbers. The effect of the preparations is also tested under conditions of artificial infection of the susceptible variety of tomatoes Elvira with the TMV under controlled conditions (in the climate chamber-POL-ECO-APARAT).

The unique structural features of spirooxindoles together with the diverse biological activities have made them privileged structures in new drug discovery. According to a large number of publications, such spiro compounds have different biological properties [1]. Among them are activities against numerous viruses. Previously, we and other authors have reported about spiro compounds that can potentially be used as anti-HIV agents, or in veterinary medicine against Bovine Viral Diarrhoea Virus (BVDV) [2,3,4]. Nowadays, compound 1 is being tested for its ability to inhibit the action of the tobacco mosaic virus- TMV, tomato spotted wilt virus-TSWV and cucumber mosaic virus-CMV.formulaTSWV infects a variety of hosts, contributing to its global economic impact on crops. There are over a thousand of different hosts for TSWV. The host range of TSWV includes economically important crops like tomatoes and tobacco. TMV is known as one of the most stable viruses. It has a very wide survival range. As long as the surrounding temperature remains below approximately 40 degrees Celsius, TMV can sustain its stable form. The effect of the tested compoundsagainst TSWV is studied on the tomatoes of Emir variety. Studies on the effects of the same compounds against CMV are conducted on Rodnichok cucumbers. The effect of the preparations is also tested under conditions of artificial infection of the susceptible variety of tomatoes Elvira with the TMV under controlled conditions (in the climate chamber-POL-ECO-APARAT).