Steroidal glycosides from the seeds of hyoscyamus niger L. and their antifungal activity
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KINTIA, Pavel; SHVETS, Stepan; FAVEL, Anna; PIZZA, Cosimo. Steroidal glycosides from the seeds of hyoscyamus niger L. and their antifungal activity. In: Chemistry Journal of Moldova. 2007, nr. 1(2), pp. 108-113. ISSN 1857-1727.
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Chemistry Journal of Moldova
Numărul 1(2) / 2007 / ISSN 1857-1727 /ISSNe 2345-1688

Steroidal glycosides from the seeds of hyoscyamus niger L. and their antifungal activity

Pag. 108-113

Kintia Pavel, Shvets Stepan, Favel Anna, Pizza Cosimo
 
Institutul de Genetica şi Fiziologie a Plantelor
 
Disponibil în IBN: 7 decembrie 2013


Rezumat

Phytochemical analysis of the seeds of Hyocyamus niger L. (Solonaceae) resulted in the isolation of six steroidal glycosides, two furostanol (1, 2) and four spirostanol saponins (3, 4, 5, 6), which were found in this plant for the first time. The structures of these compounds were determined by detailed analysis of their spectral data, including two-dimensional NMR spectroscopy and MS spectroscopy. The antifungal activity of a crude steroidal glycoside extract, fractions of spirostanoles and individual glicosides was investigated in vitro against a panel of human pathogenic fungi, yeasts as well as dermatophytes and filamentous species.

Cuvinte-cheie
Hyoscyamus niger L., steroidal glycosides,

Antifungal activity