Neamon-Hepa on Carbon Tetrachloride-Induced Hepatotoxicity: Antioxidant Properties

Todiraş Mihail; Rudik V.; Parii Sergiu; Gudumak V.; Rusnac Liliana; Golovin Pavel; Chiriac Tatiana; Valica Vladimir

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TODIRAŞ, Mihail, RUDIK, V., PARII, Sergiu, GUDUMAK, V., RUSNAC, Liliana, GOLOVIN, Pavel, CHIRIAC, Tatiana, VALICA, Vladimir. Neamon-Hepa on Carbon Tetrachloride-Induced Hepatotoxicity: Antioxidant Properties. In: Curierul Medical, 2010, nr. 4(316), pp. 3-6. ISSN 1875-0666.

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Curierul Medical

Numărul 4(316) / 2010 / ISSN 1875-0666

Neamon-Hepa on Carbon Tetrachloride-Induced Hepatotoxicity: Antioxidant Properties

Pag. 3-6

Todiraş Mihail¹, Rudik V.², Parii Sergiu¹, Gudumak V.¹, Rusnac Liliana¹, Golovin Pavel¹, Chiriac Tatiana², Valica Vladimir¹

¹ ”Nicolae Testemițanu” State University of Medicine and Pharmacy,
² Institute of Microbiology and Biotechnology of the ASM

Disponibil în IBN: 7 decembrie 2013

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The present study was undertaken to investigate whether Neamon-Hepa treatment provides antioxidant protection from chronic liver injury induced in mice by a long-term CCl4 administration. The Neamon-Hepa capsule, a combination indigene drug, contains L-arginine, Spironolactone and biopreparation from the Spirulina platensis - BioR. Carbon tetrachloride chronic treatment for three weeks significantly decreased the hepatic antioxidant enzyme activities - almost twofold superoxide dismutase enzyme activity, catalase activity, glutathione peroxidase activity in liver tissue and induced a marked elevation almost twofold of thiobarbituric acid reactive substances levels in the plasma and liver tissue. Treatment with the Neamon-Hepa following experimental liver damage, in a dose-dependent way, resulted in a marked augmentation of antioxidant enzyme activities and reduction of lipid peroxidation levels.

Антиоксидантные возможности фармацевтического препарата Неамон-Хепа при токсическом гепатите, индуцированным тетрахлоридом углерода Целью данной работы является исследование антиоксидантного воздействия лекарственного препарата Неамон- Хепа у мышей с токсическим гепатитом, индуцированным тетрахлоридом углевода. В состав комбинированного медикамента Неамон-Хепа входит аргинина аспартат, БиоР и спиронолактон. Хроническая интоксикация в течении 3 недель с ССl4 снизила в два раза активность супероксиддисмутазы, каталазы, глутатионпероскидазы в печеночной ткани и повысила вдвое степень тиобарбитуровой кислоты в печеночной ткани и в сыворотке крови. Применение препарата Неамон-Хепа значительно уменьшило степень процессов липидного пероксидирования и увеличило актив- ность антиоксидативных энзимов.

Cuvinte-cheie
Neamon-Hepa, antioxidant properties,

induced hepatotoxicity

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