New data were obtained on the molecular mechanisms of antiproliferative, antiinvasive, antiangiogenic, vasoprotective, antiatherogenic, antioxidant and anti-inflammatory action exerted by bioactive compounds. An increased interest is actually offered in the evaluation of the impact of the new copper coordination compounds (CCC) - thiosemicarbaside derivates. CCC showed important antitumoral properties, however their influence on the malondialdehyde level in the supernatant of human periferic blood by in vitro testing has not been studied. The aim was to study the influence of the new copper coordination compounds, thiosemicarbaside derivatives, on the level of malondialdehyde (MDA) of the human periferic blood by the in vitro testing. The influence of the new CCC, thiosemicarbaside derivatives, coded as CMA-18, CMC-34, CMD-8, CMG-41, CMJ-33 and doxorubicin (DOXO) in the doses of 10,0 μM/L and 1,0 μM/L was tested in vitro, according to the method developed by Atasayar S., et al. (2011), in our modification (2012) [1, 2]. The tested compounds CMA-18, CMC-34, CMD-8, CMG-41, CMJ-33 have been developed at the State University of Moldova in the Laboratory "Advanced materials in biopharmaceutics and technics" [3]. The influence of CCC and doxorubicin on the MDA level, was determined in the supernatant of human periferic blood by in vitro testing collected from 8 conventionally healthy individuals. As results the research showed different changes exerted by the new CCC on the level of MDA in conventionally healthy individuals. The study revealed that the MDA level increased statistically significant by 29%-63% by the tested compounds CMG-41, CMJ-33 and DOXO, all in the dose of 10 μM/L compared with the control group, which denotes their prooxidant effect, MDA being the final product of the peroxide oxidation of lipids. The amount of MDA level decreased conclusively by 15%-41% under the influence of compounds CMA-18 (both doses), CMC-34-10 μM/L, CMD-8 (both doses) and CMG-41-10 μM/L, compared with doxorubicin, a drug widely used in the treatment of cancer. These results denote the antioxidant effect of the tested compounds, being much more effective than doxorubicin. Conclusions: the influence of studied CCC on MDA level was selective and differentiate. Larger studies are needed in the future to find out the main mechanisms of the CCC influence.