Currently, the parasites Ichthyophthirius multifiliis (indigenous) and Neoichthyophthirius schlotfeldii (imported from Southeast Asia) are found in fish farming systems. In order to make the methods of parasite eradication more efficient, within the framework of the research we set an objective of developing and testing preparations based on super-solvents, in order to increase the speed of penetration and their permeability through the integument of aquatic organisms and the membrane of parasitic cysts of species Ichthyophthirius multifiliis and Neoichthyophthirius schlotfeldii. We took as a basis the preparation of an aqueous solution of methylene blue and basic green (oxalate), with the addition of different concentrations of dimethylsulfoxide DMSO (CH3)2SO. We have determined that the most effective veterinary antiparasitic treatment in the aforementioned ichthyophthiriosis is based on the application of the FMC preparation (3.7 g malachite green + 3.7 g methylene blue + 1 liter formaldehyde 32%). 3 variants of FMC + DMSO were prepared: 1. 1 liter of FMC + 0.1 liter of DMSO. 2. 1 liter of FMC + 0.15 liters of DMSO. 3. 1 liter of FMC + 0.2 liters of DMSO. All results were visually assessed every 24 hours. The following results were attested: 1. FMC + 0.1 DMSO (on the 6th day, a slight decrease in the number of resting cysts and reproductive cysts, a decrease in the secondary damage caused by saprolegniosis; on the 11th day - single cysts on the body and fins, no fungal lesions are noted; on the 14th day, the integument is clean, partial restoration of the epithelium begins. 2. FMC + 0.15 DMSO (on the 4th day the number of cysts decreased by 50-60%, no secondary fungal infection was attested; on the 7th day – attestation of simple cysts in the region of gill opercles and pectoral fins; on the 9th day the integument was completely cleared. 3. FMC + 0.2 l of DMSO (on the 2nd day the epithelium was 90-95% cleared of cysts, on the 3rd day the hydrobionts were completely freed from the cysts, the epithelium is restored. According to the results obtained, we can recommend to fish breeding organizations to combat tropical species of Ichthyophthirius by applying a preparation consisting of 1 l of FMC and 0.2 l of dimethylsulfoxide.