The goal of this research is to demonstrate the biological effectiveness of the Sophora flavescens extract (biologically active substance Matrine), as a potential way to control the aphids (Aphis gossypii Glov) to the tomato crops in protected areas compared to the insecticide Pelecol. Analyzing the obtained data after the first treatment in the control of aphids was observed a decrease in the number of pests compared to the untreated control. Thus, the biological efficacy of Sophora flavescens extract (at a dose of 13.0 l / ha) was on average 77,5%. The average biological efficacy of Pelecol as a standard was 87.7%. These data show that treating tomato plants with Sofhora flavescens extract in protected areas reduces the spread of aphids.