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<creators>
<creator>
<creatorName>Dumbravan, M.</creatorName>
<affiliation>Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu“, Moldova, Republica</affiliation>
</creator>
<creator>
<creatorName>Bosovschi, I.</creatorName>
<affiliation>Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu“, Moldova, Republica</affiliation>
</creator>
<creator>
<creatorName>Liscinscaia, C.</creatorName>
<affiliation>Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu“, Moldova, Republica</affiliation>
</creator>
<creator>
<creatorName>Savenco, D.</creatorName>
<affiliation>Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu“, Moldova, Republica</affiliation>
</creator>
<creator>
<creatorName>Caraman, D.</creatorName>
<affiliation>Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu“, Moldova, Republica</affiliation>
</creator>
</creators>
<titles>
<title xml:lang='en,ro'>Detection of destructive pulmonary tuberculosis in a child with COVID-19</title>
</titles>
<publisher>Instrumentul Bibliometric National</publisher>
<publicationYear>2022</publicationYear>
<relatedIdentifier relatedIdentifierType='ISSN' relationType='IsPartOf'>2345-1467</relatedIdentifier>
<subjects>
<subject>tuberculosis</subject>
<subject>COVID-19</subject>
<subject>children</subject>
<subject>uberculoză</subject>
<subject>COVID-19</subject>
<subject>copii</subject>
<subject schemeURI='http://udcdata.info/' subjectScheme='UDC'>616.24-002.5-053.2+616.98:578.834</subject>
</subjects>
<dates>
<date dateType='Issued'>2022-10-21</date>
</dates>
<resourceType resourceTypeGeneral='Text'>Journal article</resourceType>
<descriptions>
<description xml:lang='en' descriptionType='Abstract'><p>Background. TB-disease in children develops after primary contact with an adult with contagious TB in the presence of immunosuppression. The COVID-19 pandemic has reduced the number of TB cases diagnosed. WHO reports a 18% decrease in TB cases between 2019 and 2020 (from 7.1 to 5.8 million cases). Objective of the study. Presentation of the case of destructive tuberculosis detected in children with COVID-19 infection. Material and Methods. Anamnestic, clinical and paraclinical data were taken from the medical record. The patient was investigated by radiography and pulmonary tomosynthesis, microbiological examination and molecular-genetic method XPert MBT/RIF. Results. The 15-year-old patient was transferred from the RTI ward where she was being treated for pneumonia in COVID-19. The onset of the disease was manifested by intoxication and bronchopulmonary syndrome, with an episode of hemoptysis. The non-specific treatment administered resulted with torpid dynamics. Radiography and pulmonary tomosynthesis established the &ldquo;ring image&rdquo; in the right upper lobe. GeneXPert MBT/RIF &ndash; &bdquo;positive&rdquo; RIF resistant. The specific treatment regimen administered consisted of antituberculosis drugs for resistant TB. MDR TB was confirmed by bacteriological examination. At 2 and 5 months of treatment, positive clinical-radiological dynamics are followed. The tolerance of the treatment is good, the total duration of the treatment being 9-11 months. The prognosis is considered to be favorable. Conclusion. COVID-19 infection has contributed to the serious evolution and late detection of TB in this child. Microbiological confirmation of the etiology of TB is a priority for correct treatment, according to the sensitivity of Mycobacterium tuberculosis.</p></description>
<description xml:lang='ro' descriptionType='Abstract'><p>Introducere. TB-boală la copii se dezvoltă după un contact primar cu un adult cu TB contagioasă &icirc;n prezența imunosupresiei. Pandemia COVID-19 a determinat o reducere a cazurilor de TB diagnosticate. OMS raportează o scădere cu 18% a cazurilor de TB &icirc;ntre 2019 și 2020 (de la 7,1 la 5,8 milioane de cazuri). Scopul lucrării. Prezentarea cazului clinic de tuberculoză distructivă depistată la copil cu infecția COVID-19. Material și Metode. Datele anamnestice, clinice și paraclinice au fost prelevate din fișa medicală. Pacientul a fost investigat prin radiografie și tomosinteză pulmonară, examen microbiologic și metoda molecular-genetică XPert MBT/RIF. Rezultate. Pacienta - copil de 15 ani, a fost transferată din secția RTI unde s-a aflat la tratament cu pneumonie &icirc;n cadrul COVID-19. Debutul bolii s-a manifestat cu sindrom de intoxicație și bronhopulmonar, cu epizod de hemoptizie. Tratamentul nespecific administrat a rezultat cu dinamică torpidă. Radiografia și tomosinteza pulmonară a stabilit &bdquo;imagine inelară&rdquo; &icirc;n lobul superior drept. GeneXPert MBT/RIF &ndash;&rdquo;pozitiv&rdquo; RIF rezistent. Schema de tratament specific administrat a constituit din antituberculoase pentru TB rezistentă. TB MDR a fost confirmată prin examenul bacteriologic. La 2 și 5 luni de tratament se urmărește dinamică clinico-radiologică pozitivă. Toleranța tratamentului este bună, durata totală a tratamentului fiind de 9-11 luni. Pronosticul se consideră a fi favorabil. Concluzii. Infecția cu COVID-19 a contribuit la evoluție gravă complicată și depistarea tardivă a TB la acest copil. Confirmarea microbiologică a etiologiei TB este o prioritate pentru un tratament corect, conform sensibilității Mycobacterium tuberculosis.</p></description>
</descriptions>
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