There are various groups of organisms that cause damage to sunflower crop worldwide. Among these, an important constrain is represented by the weed Orobanche cumana. Sunflower broomrape is an obligate root parasite, which entirely depend on their host for the supply of carbon, nitrogen and inorganic solutes. As the effects of the attack can be mentioned the wilting of the host plants, the yellowing of the leaves, the reduction in the size of the underground and aerial parts of the plant and intensity of metabolic processes, that led to the reduction of the quantity and quality of the sunflower seeds. The impact of broomrape depends on the intensity and frequency of the attack, yield losses varying between 5-90%. The aim of present study was to analyze the influence of broomrape on some productivity indices (hectolitre weight, 1000 seeds weight and yield) in a series of experimental hybrids from the Republic Moldova in the conditions of natural infestation. In the investigations were included 20 sunflower hybrids. The obtained results revealed that the most affected by the parasite was the seed yield, a high negative correlation (r = -0.62) between this parameter and the number of attachments of O. cumana per host plant being observed. On the other hand, no significant correlations were found between intensity of the attack and hectolitre weight and weight of 1000 seeds.