Industrial symbiosis is the process by which wastes, by‐products or underused resources of an industry or industrial process become raw material or input for another. As an expression of the circular economy, it seeks environmental sustainability, maximizes resources, and generates social, environmental, and economic benefits, generating various advantages for companies and environmental benefits for society, economic competitiveness, resource efficiency and security. As a policy agenda has direct relevance not only to resource efficiency but also to a broad policy agenda covering innovation, green grow and economic development. At the EU level, Industrial Symbiosis is acknowledged in a wide range of Directives, Regulations and Strategies, aiming at providing a system transformation in policy as well as technology, production systems, finance, business models, skills, and citizen behaviour. The objective of the research is to analyse, based on the experience of other states, case studies related to industrial symbiosis development, literature review, the structure of the economy of the Republic of Moldova, the development potential of industrial symbiosis in the Republic of Moldova by adjusting applied methodologies according to the country-specific context. The study analyses policy framework, economic and regulatory context, and challenges for the implementation and proposes new paths to facilitate the model. While considering different models and approaches for developing industrial symbiosis, the research is focused on EU experience and policies.