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SM ISO690:2012 PANTEA, Valeriana, GAMANIUC, Marina, POPA, Veaceslav, TAGADIUC, Olga. Modifications of the erythrocytic antioxidant system in the administration of new coordinative compounds. In: Cercetarea în biomedicină și sănătate: calitate, excelență și performanță, Ed. 1, 20-22 octombrie 2021, Chişinău. Chișinău, Republica Moldova: 2021, p. 27. ISBN 978-9975-82-223-7 (PDF).. |
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Cercetarea în biomedicină și sănătate: calitate, excelență și performanță 2021 | ||||||
Conferința "Cercetarea în biomedicină și sănătate: calitate, excelență și performanță" 1, Chişinău, Moldova, 20-22 octombrie 2021 | ||||||
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Rezumat | ||||||
Background. Currently, there is a growing interest in new local coordination compounds (CC), which demonstrated antitumor properties, but their influence on the erythrocyte antioxidant system has not studied. Objective of the study. To study the effects of CC, thiosemicarbazide derivatives - TIA-3, TIA-160, CMT-67 and CMJ-33 on indices of the antioxidant system indicators in erythrocytes peripheral blood in vivo experiments. Material and Methods. The action of CC on superoxidismutase, catalase, total antioxidant activity was evaluated on a group of 42 white rats, randomly divided into 5 groups: the first control group was injected subcutaneously with saline; the other groups (2 - TIA-3, 3 - TIA-160, 4 - CMT-67 and 5 - CMJ-33) were given subcutaneously 3 times a week for 30 days 100 nM / kg CC. Results. It was established that the TIA-3 compound demonstrate the highest capacity to induce the expression of erythrocyte catalase that exceeded the control level of 2.6, which is strongly positively correlated with the enzymatic SOD activity. Thus, this study showed that there are differences in the mechanisms of action of thiosemicarbazone derivatives. Conclusion. The influence tested CC on the indices of the antioxidant system is selective. This selectivity may be base to their strong selective antiproliferative and cytotoxic action on tumor cells, but not on healthy ones. |
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Cuvinte-cheie Coordinating compounds, erythrocytes, Antioxidant enzymes, compuşi coordinativi, eritrocite, enzime antioxidante |
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<meta name="citation_title" content="Modifications of the erythrocytic antioxidant system in the administration of new coordinative compounds"> <meta name="citation_author" content="Pantea Valeriana"> <meta name="citation_author" content="Gamaniuc Marina"> <meta name="citation_author" content="Popa Veaceslav"> <meta name="citation_author" content="Tagadiuc Olga"> <meta name="citation_publication_date" content="2021"> <meta name="citation_collection_title" content="Cercetarea în biomedicină și sănătate: calitate, excelență și performanță"> <meta name="citation_firstpage" content="27"> <meta name="citation_lastpage" content="27"> <meta name="citation_pdf_url" content="https://ibn.idsi.md/sites/default/files/imag_file/027_0.pdf">