Coordination polymers constructed from aliphatic dicarboxylate ligands, versus those built from aromatic dicarboxylate ligands, have been less studied. The dicarboxylate linker’s length and flexibility make a decisive impact on the dimensionality and architecture of final coordination polymer. Along with the carboxylate networks, the great variety of the reported Zn(II)/Cd(II)-based coordination polymers represent the mixed-ligand systems as well as the systems with the ditopic ligands that combine both carboxylic and pyridine functions in one molecule such as nicotinic acid and its derivatives. We report herein synthesis and X-ray study for five layered coordination polymers derived from Zn(II)/Cd(II) salts, malonic acid (H2mal) and nicotinamide-like ligands, such as nicotinamide (nia), isonicotinamide (iso-nia) and thionicotinamide (S-nia):     All compounds represent the supramolecular isomers. In couples, compounds 1, 2 and 3, 4 are isostructural. Compounds 1, 2 and 5 crystallize in the noncentrosymmetric orthorhombic Pna21 space group, while 3 and 4 crystallize in the monoclinic centrosymmetric P21/n space group. Both metal atoms adjust the distorted NO5-octahedral cores provided by three identical malonate anions, acting in bidentate-chelating and monodentate bridging modes each in the equatorial plane, and with the nicotinamide ligands and water molecules that occupy two axial positions. The malonate anions are responsible for the very similar chiral 2D dense coordination networks with the (3,3) topology and the rhombohedral meshes (Fig.). The coordinated to the metals water molecules close these meshes via a couple of OH···O hydrogen bonds. The centrosymmetric packing of chiral layers in 3 and 4 provided through the NH…O centrosymmetric amide homosynthon R22(8) explains the loss of asymmetry in these compounds. The dmf molecules are held in the crystal lattices via NH···O hydrogen bonds with coordination networks. The luminescent properties of all solids and NLO properties for 1, 2, 5 are in progress. Acknowledgments. Authors thank the projects CSSDT 15.817.02.06F and 15.820.16.02.01/It for support. D.C. & L.C. acknowledge the financial support from the Grant for Young Scientists (15.819.02.03F)