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SM ISO690:2012 GULYA, Aurelian, GRAUR, Vasilii О., CHUMAKOV, Yurii, PETRENKO, Peter A., BALAN, Greta, BURDUNIUC (POPA), Olga, TSAPKOV, Victor I., RUDIK, V.. Synthesis, Structure, and Biological Activity of Copper and Cobalt Coordination Compounds with Substituted 2-(2-Hydroxybenzylidene)-N-(prop-2-en-1-yl)hydrazinecarbothioamides. In: Russian Journal of General Chemistry, 2019, vol. 89, pp. 953-964. ISSN 1070-3632. DOI: https://doi.org/10.1134/S1070363219050153 |
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Russian Journal of General Chemistry | |
Volumul 89 / 2019 / ISSN 1070-3632 /ISSNe 1608-3350 | |
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DOI: https://doi.org/10.1134/S1070363219050153 | |
Pag. 953-964 | |
Rezumat | |
The reaction of N-(prop-2-en-1-yl)hydrazinecarbothioamide with substituted 2-hydroxybenzaldehydes afforded the corresponding Schiff bases which were used as ligands to obtain copper and cobalt coordination compounds Cu(NL1–6)X · n H2O (X = Cl−, NO3−; n = 0–3), Co(HL2)2NO3, and Co(NL6)2Cl. The structure of the isolated complexes was determined by NMR spectroscopy and X-ray analysis. The complexes were tested for antimicrobial and antifungal activity against S. aureus, E. coli, and yeast-like fungi. Inhibitory effect of the initial thioamides and their complexes against human myeloid leukemia HL-60 cancer cell line was also studied. |
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Cuvinte-cheie 2-hydroxybenzaldehyde, allylthiosemicarbazones, anticancer activity, Antimicrobial activity, coordination compounds |
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