Synthesis, Structure, and Biological Activity of Copper and Cobalt Coordination Compounds with Substituted 2-(2-Hydroxybenzylidene)-N-(prop-2-en-1-yl)hydrazinecarbothioamides
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GULEA, Aurelian; GRAUR, Vasile; CHUMAKOV, Yurii; PETRENKO, Peter; BALAN, Greta; BURDUNIUC, Olga; TSAPKOV, Viktor; RUDIC, Valeriu. Synthesis, Structure, and Biological Activity of Copper and Cobalt Coordination Compounds with Substituted 2-(2-Hydroxybenzylidene)-N-(prop-2-en-1-yl)hydrazinecarbothioamides. In: Russian Journal of General Chemistry. 2019, nr. 5(89), pp. 953-964. ISSN 1070-3632.
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Russian Journal of General Chemistry
Numărul 5(89) / 2019 / ISSN 1070-3632

Synthesis, Structure, and Biological Activity of Copper and Cobalt Coordination Compounds with Substituted 2-(2-Hydroxybenzylidene)-N-(prop-2-en-1-yl)hydrazinecarbothioamides


DOI: 10.1134/S1070363219050153
Pag. 953-964

Gulea Aurelian1, Graur Vasile1, Chumakov Yurii23, Petrenko Peter2, Balan Greta4, Burduniuc Olga45, Tsapkov Viktor1, Rudic Valeriu6
 
1 State University of Moldova,
2 Institute of Applied Physics,
3 Gebze Institute of Technology,
4 ”Nicolae Testemițanu” State University of Medicine and Pharmacy,
5 National Agency for Public Health,
6 Institute of Microbiology and Biotechnology
 
Disponibil în IBN: 9 iulie 2019


Rezumat

The reaction of N-(prop-2-en-1-yl)hydrazinecarbothioamide with substituted 2-hydroxybenzaldehydes afforded the corresponding Schiff bases which were used as ligands to obtain copper and cobalt coordination compounds Cu(NL1–6)X · n H2O (X = Cl, NO3−; n = 0–3), Co(HL2)2NO3, and Co(NL6)2Cl. The structure of the isolated complexes was determined by NMR spectroscopy and X-ray analysis. The complexes were tested for antimicrobial and antifungal activity against S. aureus, E. coli, and yeast-like fungi. Inhibitory effect of the initial thioamides and their complexes against human myeloid leukemia HL-60 cancer cell line was also studied.

Cuvinte-cheie
2-hydroxybenzaldehyde, allylthiosemicarbazones, anticancer activity, Antimicrobial activity, coordination compounds