|Conţinutul numărului revistei|
| SM ISO690:2012|
GULEA, Aurelian; GRAUR, Vasile; CHUMAKOV, Yurii; PETRENKO, Piotr; BALAN, Greta; BURDUNIUC, Olga; TSAPKOV, Victor; RUDIC, Valeriu. Synthesis, Structure, and Biological Activity of Copper and Cobalt Coordination Compounds with Substituted 2-(2-Hydroxybenzylidene)-N-(prop-2-en-1-yl)hydrazinecarbothioamides. In: Russian Journal of General Chemistry. 2019, nr. 5(89), pp. 953-964. ISSN 1070-3632.
|Russian Journal of General Chemistry|
|Numărul 5(89) / 2019 / ISSN 1070-3632|
The reaction of N-(prop-2-en-1-yl)hydrazinecarbothioamide with substituted 2-hydroxybenzaldehydes afforded the corresponding Schiff bases which were used as ligands to obtain copper and cobalt coordination compounds Cu(NL1–6)X · n H2O (X = Cl−, NO3−; n = 0–3), Co(HL2)2NO3, and Co(NL6)2Cl. The structure of the isolated complexes was determined by NMR spectroscopy and X-ray analysis. The complexes were tested for antimicrobial and antifungal activity against S. aureus, E. coli, and yeast-like fungi. Inhibitory effect of the initial thioamides and their complexes against human myeloid leukemia HL-60 cancer cell line was also studied.
2-hydroxybenzaldehyde, allylthiosemicarbazones, anticancer activity, Antimicrobial activity, coordination compounds