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612.017:616.24-002.5-085.015.8 (1) |
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SM ISO690:2012 LESNIK, Evelina. Level of cytokines in patients with pulmonary drug susceptible and resistant tuberculosis. In: Moldovan Medical Journal, 2019, nr. 1(62), pp. 3-8. ISSN 2537-6373. DOI: https://doi.org/10.5281/zenodo.2589990 |
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Moldovan Medical Journal | ||||||
Numărul 1(62) / 2019 / ISSN 2537-6373 /ISSNe 2537-6381 | ||||||
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DOI:https://doi.org/10.5281/zenodo.2589990 | ||||||
CZU: 612.017:616.24-002.5-085.015.8 | ||||||
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Background: Cytokines are the regulators of the immune response in tuberculosis: TNF-alpha and CXCL8 (IL-8) are involved in the granuloma formation, IL-10 inhibits the inflammation; some chemokines increase the liver production of the acute phase proteins (APPs). The aim of the research was to assess the serum level of IL-8, TNF-alpha, IL-10, C-reactive protein (CRP), ceruloplasmin and fibrinogen in patients with drug-sensitive and multidrug resistant tuberculosis (MDR-TB). Material and methods: A prospective case-control study, which included 51 patients, distributed in 2 groups: the 1st study group (N=24 new cases with drug-sensitive TB) and the 2nd study group (N=27 new cases with MDR-TB) according to sex and age were compared with the control group (N=36 healthy individuals). Results: Serum concentration of IL-8 was elevated up to 13 times, TNF-alpha up to 4 times and IL-10 up to 2 times in study groups, compared with the reference value of the control group. Fibrinogen concentration was elevated up to 2 times in study groups compared with the control group and CRP up to 3 times compared with conventional value. Ceruloplasmin was statistically higher in the drug-sensitive TB and mildly elevated in MDR-TB group. Conclusions: Proinflammatory biomarkers are more elevated than the anti-inflammatory response, without differences among groups regarding drug sensitiveness |
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Cuvinte-cheie tuberculosis, immunity, biomarkers. |
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