Inoffensivity of imupurin in pregnancy
Închide
Conţinutul numărului revistei
Articolul precedent
Articolul urmator
665 18
Ultima descărcare din IBN:
2021-06-02 20:17
Căutarea după subiecte
similare conform CZU
615.375.035.2:618.2/.3 (1)
Medicamentele potrivit originii lor (470)
SM ISO690:2012
POGONEA, Ina, CATCOV, Carolina, GHICAVÎI, Victor. Inoffensivity of imupurin in pregnancy. In: Moldovan Medical Journal, 2019, nr. 1(62), pp. 28-30. ISSN 2537-6373. DOI: https://doi.org/10.5281/zenodo.2590005
EXPORT metadate:
Google Scholar
Crossref
CERIF

DataCite
Dublin Core
Moldovan Medical Journal
Numărul 1(62) / 2019 / ISSN 2537-6373 /ISSNe 2537-6381

Inoffensivity of imupurin in pregnancy

DOI: https://doi.org/10.5281/zenodo.2590005
CZU: 615.375.035.2:618.2/.3

Pag. 28-30

Pogonea Ina, Catcov Carolina, Ghicavîi Victor
 
”Nicolae Testemițanu” State University of Medicine and Pharmacy
 
Disponibil în IBN: 13 aprilie 2019


Rezumat

Background: Determination of imupurin inoffensivity on embryogenesis, organogenesis and teratogenesis in rats. Material and methods: The study of immupurin’s safety during pregnancy was performed on 60 rats, divided into 4 groups. Animals from the control group were given 2 ml of physiological solution (NaCl, 0.9% ), and those from the experimental groups – 2 ml of imupurin suspension, internally, 1000 mg / kg in different periods of pregnancy, to investigate embryotoxic, teratogenic and fetotoxic effect. The fetuses were monitored during the postnatal period, from birth to the age of 2 months, with appreciation of the physical development, the behavior and coordination of newborn movements, the evolution of body mass in dynamics, the teeth eruption, the appearance of the hair cover, the opening of the eyes, the ability to feed individually after removal from the female. Results: The studies have shown that the pre-implantation and post-implantation indices in the control group were 4.1 and 3.8 respectively, and in experimental groups were 4.4 and 3.3. The number of live fetuses in the investigated groups was 12.1±1.5, which did not differ from the control group, whose live fetuses were 12.3±1.9. Postnatal period indices (teeth eruption, hair cover, and eye opening) were similar in all investigated groups and corresponded to the age of the rats. Conclusions: Imupurin has been shown to have no embryotoxic, fetotoxic and negative effects on the postnatal period and may be recommended in pathologies accompanying pregnancy.