The efficiency of different antibacterial substances in small animals practice became a very important element in veterinary pharmacotherapeutics. Dogs’ kidney diseases, taking into account their incidence and severity, are situated in front of the list. Inflammatory diseases at dogs have a complex etiology (sometimes associated) and increased multiple clinical features, which involve serious therapeutically and curative troubles for clinicians. The aimof this study it was to evaluate the curative efficiency of norfloxacin in kidneys diseases of dogs. This drug is conditioned by different therapeutical preparations (injectable or oral administration) and comfortable periods between administrtations, and also its well known bioavailability in urinary structures seems to be the main reason in the recommendation for the treatment of kidney diseases. This study was performed on 31 dogs with different inflammatory kidney diseases and different clinical features after treatments with norfloxacin using injectable (batch No.1) or oral (batch No.2) administrations. The curative efficiency registered after injectable treatments was of 85,7% (n = 12, after oral administrations of 70,5% (n = 14).