The study has been effectuated for describing the evolution of late neonatal sepsis at babies with LBW, isolated bacterial spectrum in cases of neonatal sepsis (positive by blood cultures), use of antibiotics and sensitivity of germs for these preparations. Material and methods: A prospective study of cohort that included 190 babies admitted in resuscitation and intensive therapy wards, stage II of the Institute of Mother and Child care, took place during the 2009 year. For evaluating each case apart an electronic form that included general characteristics, extragenital and obstetrical anamnesis data, evolution of pregnancy and delivery, newborn data, results of bacterial profile at blood cultures, usage of antibacterial preparation was elaborated. The study was conducted according to the newborn weight at birth; we performed three types of comparisons: 1) general demographic data – mother and newborn data, 2) blood culture bacterial profile, 3) antibacterial preparation profile. Results: Among frequent risk factors associated to sepsis are the following: infectious maternal pathology, early rupture of membranes, prolonged aliqiudian period, choriomnionitis and hyperthermia at birth. Clinical manifestations distributed to organs and systems: respiratory manifestations occupy the first place (68.9%), followed by digestive ones (10.5%), cardio-vascular (6.3%) and instability of temperature (5.2%). High incidence of bacterial strains cultivated in blood cultures of newborns at NICU stage II - 30% for different microbial agents resistant to antibiotics. Cultivated microbial strains had low sensibility for ampiciline, oxaciline and high sensibility for ciprofloxaciline, prepenem, gentamicine. Conclusions: Late sepsis in NICU is being increasing and constitutes 9.4% / 1000 at LBW babies in the resuscitation and neonatal intensive therapy care.