In the XXI century were launched processes that significantly have changed the vector of world economic development and the economy of new type (innovation economy) in which the fundamental role is played by knowledge and “production of knowledge” has turned into a source of new business model and economic growth. The paper explores the premises of creating entrepreneurial universities as part of the triple spiral of knowledge (university-business-state). A special role is given to analyzing the impact of research and innovation on the development of human capital because on the long term, education and innovation systems represent the most powerful engines of economic development. Carrying out the applicative analysis allow us to make a contribution to increasing the visibility and international recognition of the research potential of Republic of Moldova, to strengthening the material for the elaboration of comparative studies, to improve the perception on the effectiveness of investment in research and development. The problem of equity-effectiveness ratio and cost-benefit ratio emerges when analyzing poignancy forms of research funding (state/private, national/international) because the consequences are profound and long-term with impact on resources and the quality of the human factor. Efficiency refers to the optimal allocation of resources which generates the greatest national income. Equity aims to reduce social and economic differences between individuals. The paper presents the major scientific research projects carried out within Alecu Russo Balti State University, being analyzed their influence on the quality of training for academics involved in research. A qualitative and relevant higher education enables students to acquire the skills, knowledge and transferable competences they need in order to succeed after graduation to integrate on the labor market.