The assessment of sediments quality from Romanian part of MONITOX Network, was established using singles indices: Single Ecological Risk Index (ErMe), Contamination Factor (CF Me), Enrichment Factor (EF Me), Geoaccumulation Index (Igeo Me) and integrated indices: Ecological Risk Index (RI), Global Pollution Index (PLI) and Nemerow Pollution Index (PI N), considering the heavy metals concentrations. The sediments were collected in 2019 and 2020, from 32 sampling points, in the system of Danube river - Black Sea, as follows: Lower Danube RO-BG (1), Lower Danube RO (10), Lower Prut RO-MD border (2), Danube Delta RO-UA border (7), Danube Delta –RO (2), Black-Sea area-RO (10). The selected heavy metals are: Cd, Cr, Cu, Pb, Zn, Mn). The samples were digested using the microwave oven Anton Paar and analysed using ICP-MS Elan DRCe Perkin Elmer. For the evaluations of defined indices, it was also used the standard quality levels and background concentrations corresponding for the selected heavy metals. At the individual and integrated levels, there were observed no important differences between 2019 and 2020 and as a general trend, the sediments from the Black Sea area are much less contaminated with heavy metals than those from the Lower Danube (Romania), attributed to the historical pollution resulting from anthropogenic activities.