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<creators>
<creator>
<creatorName>Lungu, L.V.</creatorName>
<affiliation>Institutul de Chimie, Moldova, Republica</affiliation>
</creator>
<creator>
<creatorName>Ciocârlan, A.G.</creatorName>
<affiliation>Institutul de Chimie, Moldova, Republica</affiliation>
</creator>
<creator>
<creatorName>Arîcu, A.N.</creatorName>
<affiliation>Institutul de Chimie, Moldova, Republica</affiliation>
</creator>
<creator>
<creatorName>Ilker, O.</creatorName>
<affiliation>Institutul de Chimie, Moldova, Republica</affiliation>
</creator>
<creator>
<creatorName>Barbă, A.N.</creatorName>
<affiliation>Institutul de Chimie, Moldova, Republica</affiliation>
</creator>
</creators>
<titles>
<title xml:lang='en'>Synthesis of new potential active homodrimane sesquiterpenoids with 1,3,4-thiadiazole units</title>
</titles>
<publisher>Instrumentul Bibliometric National</publisher>
<publicationYear>2019</publicationYear>
<relatedIdentifier relatedIdentifierType='ISBN' relationType='IsPartOf'>978-9975-62-428-2</relatedIdentifier>
<dates>
<date dateType='Issued'>2019</date>
</dates>
<resourceType resourceTypeGeneral='Text'>Conference Paper</resourceType>
<descriptions>
<description xml:lang='en' descriptionType='Abstract'><p>Sesquiterpenoids, especially those with a homodrimane skeleton, are natural compounds with a wide range of pharmaceutical and biological activities [1]. The 1,3,4-thiadiazole and its derivatives are considered interesting heterocycles since they possess important pharmacological activities [2]. As starting material for the synthesis of new title compounds 11-homodrim-6,8-dien-12-oic acid 2 was used. It was obtained before from commercially available sclareolide 1in 5 steps, with an overall yield of 47%, as depicted in Scheme [3]. After that coupling reaction of acid 2 with hydrazine hydrate was performed. Subsequently, was used one-pot method, that includes the interaction of the hydrazide 3 with a series of substituted isothiocyanates, without isolation of the intermediate compounds. This reaction was carried out in the presence of triethylamine (Et3N) in water, giving desired homodrimane compounds bearing 1,3,4-thiadiazole units in 72-78% yields [4].</p><p>formula</p><p>Reagents: a. NH2-NH2&middot;H2O, EtOH, delta, 5h, 85%; b. R-NCS, Et3N, H2O, delta, 18h, 72-78%. Scheme.Thesynthesis of homodrimane sesquiterpenoids with 1,3,4-thiadiazole units. The structures of compounds 4a-c were fully confirmed based on their 1H, 13C, 15N and 2D NMR data.</p></description>
</descriptions>
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