| Conţinutul numărului revistei |
| Articolul precedent |
| Articolul urmator |
 1705 0 |
 SM ISO690:2012RUS, Lucia Maria, DONICI, Elena, VALICA, Vladimir, PRISAKARI, Viorel I., TOMUTA, Ioan, SHEPEL, Diana, HEGHES, Simona Codruta, IUGA, Cristina Adela, UNCU, Livia. Development, physical-chemical characterization and in vitro antibacterial activity evaluation of a fixed-dose combination isohydrafural-methyluracil hydrophilic ointment. In: Farmacia, 2019, nr. 5(67), pp. 857-865. ISSN 0014-8237. DOI: https://doi.org/ 10.31925/farmacia.2019.5.15 |
| EXPORT metadate: Google Scholar Crossref CERIF DataCite Dublin Core |
  Farmacia |
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| Numărul 5(67) / 2019 / ISSN 0014-8237 | ||||||
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| DOI:https://doi.org/ 10.31925/farmacia.2019.5.15 | ||||||
| Pag. 857-865 | ||||||
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This research was focused on the pharmaceutical development of a novel, fixed-dose combination isohydrafural-methyluracil ointment on a water soluble base-polyethylene glycol (PEG). Differential scanning calorimetry (DSC) and Fourier transform infra-red spectroscopy (FTIR) were applied in order to determine the compatibility between active pharmaceutical ingredients (APIs) and between APIs-excipients. Nine formulations (F1-F9) were tested for: physical appearance and homogeneity, pH, viscosity and osmotic activity. The optimal formulation presented the concentrations of PEG 400-76.72%, PEG 1500-19.18% and a fixed-dose combination of 0.1% isohydrafural and 4% methyluracil. It showed higher antibacterial properties both to Gram-positive and Gram-negative bacteria than nitrofural 2% ointment (Furacilin®, Belarus). The long-term stability testing of the optimized formulation of isohydrafural and methyluracil revealed the shelf-life of two years. |
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| Cuvinte-cheie In vitro antibacterial activity, Pharmaceutical preformulation, Stability evaluation |
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<meta name="citation_title" content="Development, physical-chemical characterization and in vitro antibacterial activity evaluation of a fixed-dose combination isohydrafural-methyluracil hydrophilic ointment"> <meta name="citation_author" content="Rus Lucia Maria"> <meta name="citation_author" content="Donici Elena"> <meta name="citation_author" content="Valica Vladimir"> <meta name="citation_author" content="Prisakari Viorel I."> <meta name="citation_author" content="Tomuta Ioan"> <meta name="citation_author" content="Shepel Diana"> <meta name="citation_author" content="Heghes Simona Codruta"> <meta name="citation_author" content="Iuga Cristina Adela"> <meta name="citation_author" content="Uncu Livia"> <meta name="citation_publication_date" content="2019/10/15"> <meta name="citation_journal_title" content="Farmacia"> <meta name="citation_volume" content="67"> <meta name="citation_issue" content="5"> <meta name="citation_firstpage" content="857"> <meta name="citation_lastpage" content="865"> <meta name="citation_pdf_url" content="https://ibn.idsi.md/sites/default/files/imag_file/2019-05-art-15-Rus_Iuga_Uncu_857-865.pdf">
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