Development, physical-chemical characterization and in vitro antibacterial activity evaluation of a fixed-dose combination isohydrafural-methyluracil hydrophilic ointment

Rus Lucia Maria; Donici Elena; Valica Vladimir; Prisakari Viorel I.; Tomuta Ioan; Shepel Diana; Heghes Simona Codruta; Iuga Cristina Adela; Uncu Livia

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1693

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RUS, Lucia Maria, DONICI, Elena, VALICA, Vladimir, PRISAKARI, Viorel I., TOMUTA, Ioan, SHEPEL, Diana, HEGHES, Simona Codruta, IUGA, Cristina Adela, UNCU, Livia. Development, physical-chemical characterization and in vitro antibacterial activity evaluation of a fixed-dose combination isohydrafural-methyluracil hydrophilic ointment. In: Farmacia, 2019, nr. 5(67), pp. 857-865. ISSN 0014-8237. DOI: https://doi.org/ 10.31925/farmacia.2019.5.15

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Farmacia

Numărul 5(67) / 2019 / ISSN 0014-8237

Development, physical-chemical characterization and in vitro antibacterial activity evaluation of a fixed-dose combination isohydrafural-methyluracil hydrophilic ointment

DOI:https://doi.org/ 10.31925/farmacia.2019.5.15

Pag. 857-865

Rus Lucia Maria¹, Donici Elena², Valica Vladimir², Prisakari Viorel I.², Tomuta Ioan¹, Shepel Diana³, Heghes Simona Codruta¹, Iuga Cristina Adela¹, Uncu Livia²

¹ Iuliu Haţieganu University of Medicine and Pharmacy Cluj-Napoca,
² ”Nicolae Testemițanu” State University of Medicine and Pharmacy,
³ Institute of Chemistry

Disponibil în IBN: 26 octombrie 2019

Rezumat

This research was focused on the pharmaceutical development of a novel, fixed-dose combination isohydrafural-methyluracil ointment on a water soluble base-polyethylene glycol (PEG). Differential scanning calorimetry (DSC) and Fourier transform infra-red spectroscopy (FTIR) were applied in order to determine the compatibility between active pharmaceutical ingredients (APIs) and between APIs-excipients. Nine formulations (F1-F9) were tested for: physical appearance and homogeneity, pH, viscosity and osmotic activity. The optimal formulation presented the concentrations of PEG 400-76.72%, PEG 1500-19.18% and a fixed-dose combination of 0.1% isohydrafural and 4% methyluracil. It showed higher antibacterial properties both to Gram-positive and Gram-negative bacteria than nitrofural 2% ointment (Furacilin®, Belarus). The long-term stability testing of the optimized formulation of isohydrafural and methyluracil revealed the shelf-life of two years.

Cuvinte-cheie
In vitro antibacterial activity, Pharmaceutical preformulation, Stability evaluation

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<dc:creator>Rus, L.</dc:creator>
<dc:creator>Donici, E.V.</dc:creator>
<dc:creator>Valica, V.V.</dc:creator>
<dc:creator>Prisacari, V.I.</dc:creator>
<dc:creator>Tomuta, I.</dc:creator>
<dc:creator>Şepeli, D.F.</dc:creator>
<dc:creator>Heghes, S.</dc:creator>
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<dc:creator>Uncu, L.V.</dc:creator>
<dc:date>2019-10-15</dc:date>
<dc:description xml:lang='en'><p>This research was focused on the pharmaceutical development of a novel, fixed-dose combination isohydrafural-methyluracil ointment on a water soluble base-polyethylene glycol (PEG). Differential scanning calorimetry (DSC) and Fourier transform infra-red spectroscopy (FTIR) were applied in order to determine the compatibility between active pharmaceutical ingredients (APIs) and between APIs-excipients. Nine formulations (F1-F9) were tested for: physical appearance and homogeneity, pH, viscosity and osmotic activity. The optimal formulation presented the concentrations of PEG 400-76.72%, PEG 1500-19.18% and a fixed-dose combination of 0.1% isohydrafural and 4% methyluracil. It showed higher antibacterial properties both to Gram-positive and Gram-negative bacteria than nitrofural 2% ointment (Furacilin&reg;, Belarus). The long-term stability testing of the optimized formulation of isohydrafural and methyluracil revealed the shelf-life of two years.</p></dc:description>
<dc:identifier> 10.31925/farmacia.2019.5.15</dc:identifier>
<dc:source>Farmacia 67 (5) 857-865</dc:source>
<dc:subject>In vitro antibacterial activity</dc:subject>
<dc:subject>Pharmaceutical preformulation</dc:subject>
<dc:subject>Stability evaluation</dc:subject>
<dc:title>Development, physical-chemical characterization and in vitro antibacterial activity evaluation of a fixed-dose combination isohydrafural-methyluracil hydrophilic ointment</dc:title>
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