This material represents a scientific synthesis study on the distribution of habitats of the most vulnerable plant species in Moldova threatened with extinction (according to CITES, 1973), consequence of illegal exploitation for temporary benefits or as a result of degradation of habitats and ecosystems, caused by the anthropic factor. At the same time, ample and multilateral information on the spread, biology, ecology and protection of these plant species will provide answers to some major challenges of the millennium and will contribute to the realization of argued scientific management and monitoring.