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|Medicamentele potrivit originii lor (179)|
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APOSTOL, Theodora-Venera; SOCEA, Laura-Ileana; BARBUCEANU, Stefania-Felicia; SARAMET, Ioana; OLARU, Octavian-Tudorel; DRAGHICI, Constantin. Synthesis, characterization and phytobiological evaluation of new 2-[4-(4-bromophenylsulfonyl)phenyl]- 4-methyloxazol-5(4h)-one and some new 5-aryl-2-[4-(4-bromophenylsulfonyl)phenyl]-4-methyloxazoles . In: Revista Farmaceutică a Moldovei . 2014, nr. 3-4, p. 45. ISSN 1812-5077.
|Revista Farmaceutică a Moldovei|
|Numărul 3-4 / 2014 / ISSN 1812-5077|
Heterocyclic compounds containing 1,3-oxazol-5(4H)-one and 1,3-oxazole ring are important targets in synthetic and medicinal chemistry, because of their applications as potentially active compounds. Thus, some 1,3-oxazol-5(4H)-ones have been reported to present antimicrobial and antitumor activity. 1,3-Oxazoles are frequent substructures in various biologically active compounds used in therapeutics as anti-inflammatory (e.g. Oxaprozin, Romazarit, Ditazol, Isamoxole), analgesic (e.g. Oxaprozin), antibacterial, antifungal (e.g. Sulfamoxole, Sulfaguanole), muscle relaxant (e.g. Azumolene) drugs. Therefore, there is considerable interest to synthesize new 1,3-oxazole5(4H)-ones and 1,3-oxazoles which contain 4-(4-bromophenylsulfonyl) phenyl moiety in 2 position with a hope to obtain potent biologically active compounds. The plant growth regulatory effects of the new compounds were examined.