A sequential dual cleavage of the arylsulfamate linker to provide both sulfamate and phenol derivatives

Fournier Diane; Ciobanu Liviu; Poirier Donald

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818

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2017-04-12 22:04

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similare conform CZU

547.466:542.95 (1)

Chimie organică (484)

Reacţii chimice. Procese chimice speciale (67)

SM ISO690:2012

FOURNIER, Diane, CIOBANU, Liviu, POIRIER, Donald. A sequential dual cleavage of the arylsulfamate linker to provide both sulfamate and phenol derivatives. In: Chemistry Journal of Moldova, 2015, nr. 2(10), pp. 68-76. ISSN 1857-1727. DOI: https://doi.org/10.19261/cjm.2015.10(2).09

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Chemistry Journal of Moldova

Numărul 2(10) / 2015 / ISSN 1857-1727 /ISSNe 2345-1688

A sequential dual cleavage of the arylsulfamate linker to provide both sulfamate and phenol derivatives

DOI:https://doi.org/10.19261/cjm.2015.10(2).09

CZU: 547.466:542.95

Pag. 68-76

Fournier Diane, Ciobanu Liviu, Poirier Donald

CHU de Quebec – Research Center (CHUL, T4)

Disponibil în IBN: 28 decembrie 2015

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Rezumat

Tyramine sulfamate was linked to the trityl chloride resin and this polymeric solid support used to introduce two levels of molecular diversity by formation of peptide bonds. A dual cleavage strategy next generated in a sequential way (without resin split) two different types of compounds (phenol and arylsulfamate derivatives), which are therapeutically attractive types of compounds. Here, we used tyramine as a general scaffold, but other arylsulfamate derivatives could be judiciously used to extend the nature of synthesized compounds.

Cuvinte-cheie
solid-phase synthesis, linker, sulfamate,

phenol,

library

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