A sequential dual cleavage of the arylsulfamate linker to provide both sulfamate and phenol derivatives
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547.466:542.95 (1)
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Reacţii chimice. Procese chimice speciale (67)
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FOURNIER, Diane, CIOBANU, Liviu, POIRIER, Donald. A sequential dual cleavage of the arylsulfamate linker to provide both sulfamate and phenol derivatives. In: Chemistry Journal of Moldova, 2015, nr. 2(10), pp. 68-76. ISSN 1857-1727. DOI: https://doi.org/10.19261/cjm.2015.10(2).09
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Chemistry Journal of Moldova
Numărul 2(10) / 2015 / ISSN 1857-1727 /ISSNe 2345-1688

A sequential dual cleavage of the arylsulfamate linker to provide both sulfamate and phenol derivatives
DOI:https://doi.org/10.19261/cjm.2015.10(2).09
CZU: 547.466:542.95

Pag. 68-76

Fournier Diane, Ciobanu Liviu, Poirier Donald
 
CHU de Quebec – Research Center (CHUL, T4)
 
 
Disponibil în IBN: 28 decembrie 2015


Rezumat

Tyramine sulfamate was linked to the trityl chloride resin and this polymeric solid support used to introduce two levels of molecular diversity by formation of peptide bonds. A dual cleavage strategy next generated in a sequential way (without resin split) two different types of compounds (phenol and arylsulfamate derivatives), which are therapeutically attractive types of compounds. Here, we used tyramine as a general scaffold, but other arylsulfamate derivatives could be judiciously used to extend the nature of synthesized compounds.

Cuvinte-cheie
solid-phase synthesis, linker, sulfamate,

phenol,

library

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<dc:creator>Fournier, D.</dc:creator>
<dc:creator>Ciobanu, L.</dc:creator>
<dc:creator>Poirier, D.</dc:creator>
<dc:date>2015-12-14</dc:date>
<dc:description xml:lang='en'>Tyramine sulfamate was linked to the trityl chloride resin and this polymeric solid support used to introduce two levels of molecular diversity by formation of peptide bonds. A dual cleavage strategy next generated in a sequential way (without resin split) two different types of compounds (phenol and arylsulfamate derivatives), which are therapeutically attractive types of compounds. Here, we used tyramine as a general scaffold, but other arylsulfamate derivatives could be judiciously used to extend the nature of synthesized compounds. </dc:description>
<dc:identifier>10.19261/cjm.2015.10(2).09</dc:identifier>
<dc:source>Chemistry Journal of Moldova 10 (2) 68-76</dc:source>
<dc:subject>solid-phase synthesis</dc:subject>
<dc:subject>linker</dc:subject>
<dc:subject>sulfamate</dc:subject>
<dc:subject>phenol</dc:subject>
<dc:subject>library</dc:subject>
<dc:title>A sequential dual cleavage of the arylsulfamate linker to provide both sulfamate and phenol derivatives</dc:title>
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