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<creators>
<creator>
<creatorName>Cotorobai, T.</creatorName>
<affiliation>Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu“, Moldova, Republica</affiliation>
</creator>
<creator>
<creatorName>Cotelea, T.M.</creatorName>
<affiliation>Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu“, Moldova, Republica</affiliation>
</creator>
</creators>
<titles>
<title xml:lang='ro'>Metoclopramida – medicament antiemetic şi gastroprokinetic,substrat şi inhibitor al citocrom p450 cyp 2d6
</title>
</titles>
<publisher>Instrumentul Bibliometric National</publisher>
<publicationYear>2010</publicationYear>
<relatedIdentifier relatedIdentifierType='ISSN' relationType='IsPartOf'>1857-1719</relatedIdentifier>
<dates>
<date dateType='Issued'>2010-10-01</date>
</dates>
<resourceType resourceTypeGeneral='Text'>Journal article</resourceType>
<descriptions>
<description xml:lang='en' descriptionType='Abstract'>Metoclopramide –the gastroprokinetic and antiemetic drug, substrate and inhibitor of Cytochrome P450 2D6
Based on a study of selective sciens was characterized the farmacokinetics of metoclopramide monohydrochloride, the interaction between metoclopramide and Cytocrome P450, the ability of the substance to inhibit drug – metabolizing P450 CYP 2D6 and CYP 3A. There were made conclusions regarding the influence of isoform –specific inhibitors P450 drugs on the metabolism of metoclopramide and formation of monodeethylmetoclopramide, presumably causal factor of the toxic effects of this substances. These conclusions as a good basis for further research in vivo and for an effective pharmacotherapy to patients.</description>
<description xml:lang='ro' descriptionType='Abstract'>În baza studiului literaturii ştiinţifice, s-a analizat caracteristica farmacocinetică a
clorhidratului de metoclopramidă, interacţiunea dintre metoclopramidă şi sistemul citocromului P450, capacitatea substanţei de analizat de a inhiba izoformele CYP 2D6 şi CYP 3A a P450. Sau facut concluzii despre influienţa unor medicamente specific-inhibitoare de izoforme P450 asupra metabolismului metoclopramidei şi formării metabolitului monodietilmetoclopramida, presupus factor cauzal al efectelor toxice ale acestei substante medicamentoase. Aceste concluzii servesc ca o bună bază pentru cercetările ulterioare in vivo şi pentru o farmacoterapie eficientă a pacienţilor.</description>
</descriptions>
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<format>application/pdf</format>
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