Metoclopramida – medicament antiemetic şi gastroprokinetic,substrat şi inhibitor al citocrom p450 cyp 2d6

Cotorobai Tatiana; Cotelea Tamara

Conţinutul numărului revistei

Articolul precedent

Articolul urmator

1657

Ultima descărcare din IBN:
2023-09-09 14:58

SM ISO690:2012

COTOROBAI, Tatiana, COTELEA, Tamara. Metoclopramida – medicament antiemetic şi gastroprokinetic,substrat şi inhibitor al citocrom p450 cyp 2d6 . In: Analele Ştiinţifice ale USMF „N. Testemiţanu”, 2010, nr. 1(11), pp. 439-443. ISSN 1857-1719.

EXPORT metadate:
Google Scholar
Crossref
CERIF

DataCite
Dublin Core

Analele Ştiinţifice ale USMF „N. Testemiţanu”

Numărul 1(11) / 2010 / ISSN 1857-1719

Metoclopramida – medicament antiemetic şi gastroprokinetic,substrat şi inhibitor al citocrom p450 cyp 2d6

Pag. 439-443

Cotorobai Tatiana, Cotelea Tamara

Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu“

Disponibil în IBN: 16 decembrie 2013

Descarcă PDF

Rezumat

Metoclopramide –the gastroprokinetic and antiemetic drug, substrate and inhibitor of Cytochrome P450 2D6 Based on a study of selective sciens was characterized the farmacokinetics of metoclopramide monohydrochloride, the interaction between metoclopramide and Cytocrome P450, the ability of the substance to inhibit drug – metabolizing P450 CYP 2D6 and CYP 3A. There were made conclusions regarding the influence of isoform –specific inhibitors P450 drugs on the metabolism of metoclopramide and formation of monodeethylmetoclopramide, presumably causal factor of the toxic effects of this substances. These conclusions as a good basis for further research in vivo and for an effective pharmacotherapy to patients.

În baza studiului literaturii ştiinţifice, s-a analizat caracteristica farmacocinetică a clorhidratului de metoclopramidă, interacţiunea dintre metoclopramidă şi sistemul citocromului P450, capacitatea substanţei de analizat de a inhiba izoformele CYP 2D6 şi CYP 3A a P450. Sau facut concluzii despre influienţa unor medicamente specific-inhibitoare de izoforme P450 asupra metabolismului metoclopramidei şi formării metabolitului monodietilmetoclopramida, presupus factor cauzal al efectelor toxice ale acestei substante medicamentoase. Aceste concluzii servesc ca o bună bază pentru cercetările ulterioare in vivo şi pentru o farmacoterapie eficientă a pacienţilor.

Crossref XML Export

<?xml version='1.0' encoding='utf-8'?>
<doi_batch version='4.3.7' xmlns='http://www.crossref.org/schema/4.3.7' xmlns:xsi='http://www.w3.org/2001/XMLSchema-instance' xsi:schemaLocation='http://www.crossref.org/schema/4.3.7 http://www.crossref.org/schema/deposit/crossref4.3.7.xsd'>
<head>
<doi_batch_id>ibn-2884</doi_batch_id>
<timestamp>1714508991</timestamp>
<depositor>
<depositor_name>Information Society Development Instiute, Republic of Moldova</depositor_name>
<email_address>idsi@asm.md</email_address>
</depositor>
<registrant>Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu“</registrant>
</head>
<body>
<journal>
<journal_metadata>
<full_title>Analele Ştiinţifice ale USMF  „N. Testemiţanu”</full_title>
<issn media_type='print'>18571719</issn>
</journal_metadata>
<journal_issue>
<publication_date media_type='print'>
<year>2010</year>
</publication_date>
<issue>1(11)</issue>
</journal_issue>
<journal_article publication_type='full_text'><titles>
<title>Metoclopramida – medicament antiemetic şi gastroprokinetic,substrat şi inhibitor al citocrom p450 cyp 2d6
</title>
</titles>
<contributors>
<person_name sequence='first' contributor_role='author'>
<given_name>Tatiana</given_name>
<surname>Cotorobai</surname>
</person_name>
<person_name sequence='additional' contributor_role='author'>
<given_name>Tamara</given_name>
<surname>Cotelea</surname>
</person_name>
</contributors>
<publication_date media_type='print'>
<year>2010</year>
</publication_date>
<pages>
<first_page>439</first_page>
<last_page>443</last_page>
</pages>
</journal_article>
</journal>
</body>
</doi_batch>