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![]() SOLONARI, Rodica. Aspecte biofarmaceutice şi farmacocinetice de administrare a captoprilului la copii
. In: Analele Ştiinţifice ale USMF „N. Testemiţanu”, 2010, nr. 1(11), pp. 460-465. ISSN 1857-1719. |
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Analele Ştiinţifice ale USMF „N. Testemiţanu” | ||||||
Numărul 1(11) / 2010 / ISSN 1857-1719 | ||||||
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Pag. 460-465 | ||||||
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Biopharmaceutical and pharmacokinetic aspects of captopril administration in children
The main pharmacokinetic parameters and molecular structure data of captopril were
highlighted. On the basis of this parameters of molecular structural data correspondency to
Lipinski's rule or "rule of five” were established. The percentage of ionized molecules of
captopril was calculated in different segments of the gastrointestinal tract. According to these
data the oral administration of captopril do not create problems of absorption. |
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