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SM ISO690:2012 DUKA, Gh., IVANCIC, Albert, BOLDESCU, Veaceslav. Cyclodextrins – fields of application. part II. In: Chemistry Journal of Moldova, 2012, nr. 2(7), pp. 39-45. ISSN 1857-1727. |
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Chemistry Journal of Moldova | ||||||
Numărul 2(7) / 2012 / ISSN 1857-1727 /ISSNe 2345-1688 | ||||||
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Pag. 39-45 | ||||||
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This paper represents an analysis of potential and current applications of cyclodextrins as biologically active substances in medicine. The main applications described here include use of cyclodextrins as agents that form inclusion complexes with endogenous substances (membrane lipids, cellular cholesterol), agents that form inclusion
complexes with exogenous substances with their man role as guest molecules (sugammadex, FBCx), agents that block endogenous and exogenous macromolecules (ion channels, anthrax toxin, α-hemolysin), and agents which activity is based on the chemical nature of them and of their derivatives (cyclodextrin polysulphate derivatives). The fi rst classification for medically important biological activity of cyclodextrins has been proposed. |
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Cuvinte-cheie cyclodextrins, pharmaceuticals, medicine, inclusion complexes. |
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